Imaging Core (Core C)

总结：核心C-成像核心 成像核心支持哈佛大脑老化研究（HABS）计划项目资助（PPG）， 监督所有成像协议的采集和分析。对于更新，成像核心将具有 主要负责采集11 C匹兹堡化合物B（PiB）和 18F Flortaucipir（FTP）。核心将负责基础MRI的采集和分析处理 序列，以生成所有HABS参与者的标准体积MRI变量，包括PET采样 在MRI定义的感兴趣区域（ROI）中。核心将提供BASE协议图像数据， 高级成像方案（项目3），包括FDG、R1和TARP。所有核心图像数据将 与来自核心B的数据整合：DataCentral数据库内的临床核心，由核心D监督： 分析核心。结合分析核心，项目1至4的人员将能够 查询数据库，以获取完全质量受控的图像数据，用于测试单个项目 假设对于淀粉样蛋白和tau蛋白沉积的初步评估，核心将提供标准的完整评估。 用于PiB PET的动态协议和用于FTP PET的标准后帧协议（Aim 1）。Base MRI 方案将包括用于受试者表征的一组标准化结构和功能采集， 包括皮质下体积测量，例如，海马和皮质厚度（目标1）。标准措施 核心小组从这些数据集中得出的数据将被所有四个项目用来实现各个项目的目标 (Aim 2）。这些包括淀粉样蛋白和tau的替代测量，其被实现为个体或聚集的PET指标。 组织ROI，例如，全球淀粉样蛋白负荷表示为PiB分布体积比（DVR）或区域tau 负荷表示为下颞部FTP标准摄取率（SUVr）。加工管道有 使用基于FreeSurfer、SPM 12、FSL和内部脚本的工具组合实现自动化， 程序. Imaging Core将为四个PPG项目提供质量检查MRI和PET ROI数据 已在分析核心的监督下存档和管理。成像核心是 由一组强大的临床神经影像学研究者组成，他们接受过放射学方面的专门培训， 神经学，心理学，信息学和计算机科学，谁将监督一个专门的研究人员， 与研究人员密切合作，进行MRI和PET采集、数据处理和分析 项目成像核心将协助各个项目优化每个成像措施，用于特定的 分析。

SUMMARY: CORE C- IMAGING CORE The Imaging Core supports the Harvard Aging Brain Study (HABS) Program Project Grant (PPG) by overseeing the acquisition and analyses of all imaging protocols. For the renewal, the Imaging Core will have primary responsibility for the acquisition of the PET protocols for both 11C Pittsburgh Compound B (PiB) and 18F Flortaucipir (FTP). The Core will be responsible for acquisition and analytic processing of the BASE MRI sequences to generate standard volumetric MRI variables for all HABS participants, including sampling of PET in MRI-defined regions-of-interest (ROI). The Core will provide BASE protocol image data for use with the ADVANCED Imaging protocol (Project 3), which includes FDG, R1, and TARP. All Core image data will be integrated with data from Core B: Clinical Core within the DataCentral database with oversight by Core D: Analytic Core. In conjunction with the Analytic Core, personnel from each of Projects 1 through 4 will be able to query the database to acquire fully quality-controlled image data for use in testing individual Project hypotheses. For the primary assessments of amyloid and tau deposition, the Core will provide a standard full dynamic protocol for PiB PET and a standard late-frame protocol for FTP PET (Aim 1). The BASE MRI protocol will consist of a standardized set of structural and functional acquisitions for subject characterization, including subcortical volumetrics, e.g., hippocampus, and cortical thickness (Aim 1). Standard measures derived from these data sets by the Core will be used by all four Projects to accomplish individual Project aims (Aim 2). These include proxy measures of amyloid and tau realized as PET metrics in individual or aggregated tissue ROI, e.g., global amyloid burden represented as PiB distribution volume ratio (DVR), or regional tau burden represented as inferior temporal FTP standardized uptake ratio (SUVr). The processing pipelines have been automated using a combination of tools based on FreeSurfer, SPM12, FSL, and in-house scripts and programs. The Imaging Core will supply the four PPG Projects with quality-checked MRI and PET ROI data that has been archived and managed under the supervision of the Analytic Core. The Imaging Core is composed of a strong group of clinical neuroimaging investigators, with specialized training in radiology, neurology, psychology, informatics, and computer science, who will supervise a dedicated research staff to perform MRI and PET acquisitions, data processing, and analyses in close collaboration with the research Projects. The Imaging Core will assist individual Projects to optimize each imaging measure for use in specific analyses.