Origins of Renal Physiology

项目总结/摘要 MDI生物实验室寻求NIDDK R25对第十四届至第十八届年度产品的支持， 为期一周的肾脏研究员课程，肾脏生理学的起源。该课程将于2023年8月至 2027年在缅因州巴尔港的MDI生物实验室校园。拟议的课程提供肾脏研究员 与动手研究教育的基本概念的稳态，并暴露他们的经典 肾脏生理学和肾脏病学的基础实验。 提出了八个课程模块：肾小球滤过和肾脏疾病的遗传学，近端小管功能， 升支粗，盐分泌和平衡，集合管钠转运/ENaC，水稳态， 肾结石和酸碱平衡。八个模块中的每一个都在三个连续的两天内运行 轮换（周一至周二、周三至周四和周五至周六），每次轮换的第一天 第一天是密集的实验工作，第二天是分析和向大会介绍工作。 整个课程组。每个学员将在三次轮调期间完成八个计划单元中的三个。 一个基于案例研究的负责任行为研究计划将包括在所有的时间表 参与者 肾脏生理学的起源在全国肾脏短期课程中是完全独特的。本课程提供 参与者使用研究工具，使他们更深入地了解生理稳态的概念 这在正常的临床训练计划中是难以达到的。该课程是开放给肾脏研究员，因为 2010年，在可用空间的基础上，住院医生进入肾病科。研究员和住院医生都受益 来自于与领导课程模块的肾生理学高级研究者的密切互动。居民，在 特别是，通过与来自不同项目的研究员合作并分享他们对肾脏研究的见解， 和肾病学。 该课程在MDI生物实验室网站上进行了描述，并在J. Am. Soc. of 肾病学（Zeidel等人，J.J. 19：649-50，2008）。申请的资金将用于支付课程学费和参与者费用 差旅费;教职员工生活费、津贴和差旅费;设施使用费;咨询服务费;以及人事费 管理研究教育计划所需的。

Project Summary / Abstract MDI Biological Laboratory seeks NIDDK R25 support for the fourteenth through eighteenth annual offerings of a one-week course for renal fellows, Origins of Renal Physiology. The course will be held August 2023 through 2027 on the MDI Biological Laboratory campus in Bar Harbor, Maine. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Eight course modules are proposed: glomerular filtration and genetics of renal disease, proximal tubule function, thick ascending limb, salt secretion and balance, collecting duct sodium transport/ENaC, water homeostasis, renal stone disease, and acid/base homeostasis. Each of the eight modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday-Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the eight planned modules during the three rotations. A case study-based Responsible Conduct in Research program will be included in the schedule for all participants. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDI Biological Laboratory website, and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, stipends, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.