Temple Strategies to Innovate EmeRgENcy Care Clinical Trials Network (Temple-SIREN)

坦普尔领导的紧急护理研究网络(TEMPLE-SIREN)由费城、新泽西州、特拉华州和马里兰州的多个社区和学术医疗中心以及EMS提供者组成，以执行SIREN紧急护理试验。为了满足特定研究招生的需要，坦普尔-塞伦启用了该地区容量最大的急救和创伤中心以及最繁忙的EMS系统。这一大型轴辐式网络服务于人口稠密城市和高度富裕的郊区至荷兰巴克斯县和伯克斯县的农村地区的不同人群。Temple-Siren Hub and Spoke Leaders致力于紧急护理研究，并积极参与急性心肺和神经疾病试验以及创伤性脑损伤试验。通过合作和中心监督，Temple-Sieren小组预计将对Sieren研究的注册人数做出重大贡献。此外，我们计划通过将临床前工作转移到床边，并利用我们高度多样化的区域网络进行研究，以满足我们不同社区的需求，从而保持领先地位。寺庙警笛中心的工作人员将与参与的现场调查人员和来自多个学科的协调员密切合作，以有效地执行警笛研究。提高跨站点临床研究的效率和质量的机制包括使用通用信息系统来确定潜在的研究患者；通过网络研讨会和电话会议与研究人员和协调员进行频繁的沟通；专注于良好的临床研究实践和合规性的勤奋的站点管理，以及定期的中心辐射式会议，以根据研究角色提供额外的培训。研究人员和协调人将参加SERERN临床协调中心和数据管理中心，以及特设工作组，开展SERERN研究。Temple-Siren Hub团队将从参与这种协调的紧急护理研究方法中受益，费城和我们的医院和EMS系统所服务的周围社区的人民也将受益。

The Temple-led Emergency care research network (Temple-SIREN) is comprised of multiple community and academic medical centers and EMS providers throughout Philadelphia, New Jersey, Delaware, and Maryland to execute SIREN emergency care trials. To meet the needs for specific study enrollment, Temple-SIREN engaged the highest volume emergency and trauma centers and the busiest EMS systems in the region. This large hub-spoke network serves very diverse populations in densely populated cities as well as highly affluent suburban areas to rural regions of Bucks and Berks counties in PA Dutch country. Temple-SIREN Hub and spoke leaders are committed to emergency care research and are active in trials of acute cardiopulmonary and neurological illness and traumatic brain injury trials. Through collaboration and hub oversight, the Temple-SIREN group expects to significantly contribute SIREN studies' enrollment. In addition, we plan to stay ahead of the curve by translating preclinical work to the bedside and using our highly diverse regional network for studies that needs of our diverse communities. The Temple-SIREN Hub staff will work closely with participating site investigators and coordinators from multiple disciplines to efficiently execute SIREN studies. Mechanisms to enhance efficiency and quality of clinical research across sites include use of a common informatics system to identify potential study patients; frequent communication with investigators and coordinators via webinars and conference calls; diligent site management focused on good clinical research practices and compliance, and regular Hub-spoke meetings to provide additional training by study role. Temple-SIREN investigators and coordinators will participate in SIREN clinical coordinating center and data management center and ad hoc working groups to develop SIREN studies. The Temple-SIREN Hub team would benefit from participating in this coordinated approach to emergency care research as would the people of Philadelphia and the surrounding communities served by our hospitals and EMS systems.