Trace Elements (TE)

项目摘要/摘要：跟踪元素 无机元素的化学与癌症的研究密不可分。这一点对于 我们的集水区，考虑到“花岗岩之州”典型的高水平无机元素暴露。是否 研究已知的致癌物，如砷，元素，如硒的潜在拮抗作用， 或铂或铁纳米粒子的治疗用途，显然需要常规和高级 支持NCCC研究的微量元素分析方法。微量元素(TE)共享资源 提供对癌症所有四个研究项目进行低水平无机元素分析的途径 中心。TE使用最先进的电感耦合等离子体质谱仪器来定量多种元素，当与 层析，多种污染物化合物(种)在各种生物和环境中 媒体。尖端的电感耦合等离子体质谱仪器(例如，三四极电感耦合等离子体质谱仪)提供快速、干扰- 对已建立的和新出现的污染物以及宏观和微观营养元素进行免费分析。广度 TE处理的样本类型跨越水、土壤、沉积物、无脊椎动物、鱼类和动物组织和器官， 细胞裂解物、人的头发、脚趾甲、血液、尿液、胎盘、食品和饮料。处理这种情况的能力 种类繁多的样品是TE的一个独特特点。在某些情况下，可用于分析的样本量 IS&lt；10 mg，方法通常适用于在个案的基础上考虑小样本质量。 必须根据公认的样品制备、分析和质量协议收集分析数据 控制力。TE已经建立了协议和质量保证计划，使用基于 CDC、FDA、EPA和USGS；并参与国家和国际水平测试计划，以 确保数据准确、精确且具有防御性。TE与癌症人口科学有着非常紧密的联系 (CPS)计划。TE是国际公认的化学元素低水平分析中心， 它们在生物组织中的化合物。TE已经为其他27家美国学术机构提供了服务 过去的资金周期，并在提供最先进的痕量元素分析服务方面实现了独特的利基市场 分析。在上一个资助周期中，TE为来自所有4个NCCC的12个NCCC成员运行了6721个样本 程序(CPS[1]、CBT[1]、ICI[2]和TEC[8])。资助的NCCC成员占15%(10%) 总用户数，我们仅要求CCSG支持部门提供总TE预算的3%。CPS的一个焦点 该计划是生命早期接触砷，TE是测定和确定砷的形态不可或缺的一部分。 这个项目。这项工作直接为国家和国家公共卫生政策提供了信息。例如，美国FDA 宣布2016年婴儿谷物中无机砷的拟议限量为100 ppb。对于TEC计划，TE 提供了一种测定动物组织中纳米铁的方法。TE为CBT调查人员做出了贡献 监测铂类药物的疗效。TE显然是一种基本的、高效的和高影响力的 继续在NCCC研究中发挥关键作用的资源。

Project Summary/Abstract: Trace Elements The chemistry of inorganic elements is linked inextricably with the study of cancer. This is especially true for our catchment area, given the high level of inorganic element exposures typical of “the Granite State”. Whether studying known carcinogens, such as arsenic, the potential antagonistic effects of elements, such as selenium, or the therapeutic uses of platinum or iron nanoparticles, there is a clear need for both routine and advanced trace element analytical methods to support NCCC research. The Trace Elements (TE) Shared Resource provides access to low-level inorganic elemental analysis to all four research programs within the Cancer Center. TE uses state-of-the-art ICP-MS instruments to quantify multiple elements and, when coupled with chromatography, multiple contaminant compounds (species) in a variety of biological and environmental media. Cutting-edge ICP-MS instrumentation (e.g., triple-quadrupole ICP-QQQ) provides rapid, interference- free analysis of established and emerging contaminants and macro- and micro-nutrient elements. The breadth of sample types handled by TE spans water, soil, sediment, invertebrates, fish and animal tissues and organs, cell lysates, human hair, toenail, blood, urine, placenta, foodstuffs, and beverages. The ability to handle such a broad array of sample types is a unique feature of TE. In some cases, the sample mass available for analysis is <10 mg, and methods often are adapted to account for small sample masses on a case-by-case basis. Analytical data must be collected according to accepted protocols for sample preparation, analysis, and quality control. TE has established protocols and a Quality Assurance program, uses methods based on those of the CDC, FDA, EPA, and USGS; and participates in national and international proficiency testing programs to ensure accurate, precise, and defensible data. TE has very strong links to the Cancer Population Sciences (CPS) Program. TE is an internationally-recognized center for low-level analysis of chemical elements and their compounds in biological tissues. TE has provided services for 27 other US academic institutions over the past funding cycle and fulfills a unique niche in providing state-of-the-art analytical services in trace elemental analysis. Over the last funding cycle, TE has run 6,721 samples for 12 NCCC Members from all 4 NCCC Programs (CPS [1], CBT [1], ICI [2], and TEC [8]). Funded NCCC Members have represented 15% (10) of Total Users, and we are requesting only 3% of the Total TE Budget from CCSG support. One focus of the CPS Program is early life exposure to arsenic, and TE is integral to the determination and speciation of arsenic for this project. This work has directly informed state and national public health policy. For example, the US FDA announced a proposed limit for inorganic arsenic in infant cereal of 100 ppb in 2016. For the TEC Program, TE provided a method for measuring iron nanoparticles in animal tissue. TE has contributed to CBT investigators monitoring the therapeutic effects of platinum. TE is demonstrably an essential, efficient and high-impact resource that continues to play a pivotal role in NCCC research.