Africa Center for Biostatistical Excellence: Expanding biostatistical leadership for HIV/AIDS and TB Research

项目总结 LMIC：南非 机构：开普敦斯泰伦博什大学医学与健康科学学院 科学领域：艾滋病毒/艾滋病和结核病的生物统计研究设计和方法 非洲生物统计卓越中心：扩大艾滋病毒/艾滋病生物统计领导地位 结核病研究 这项申请是对FOA“Fogarty中低档艾滋病毒研究培训计划”的响应。 D43赠款机制(FOA PAR-19-283)下的“收入国家机构”，并要求5年 支持扩大生物统计学在StellenBosch大学艾滋病毒研究设计和方法学方面的领导地位 在南非。 艾滋病毒/艾滋病和结核病仍然是撒哈拉以南非洲疾病负担的最大贡献者。这个 感染新型SARS-CoV-2病毒导致的新冠肺炎疾病对脆弱人群构成威胁 SSA的医疗系统和基础设施。特别是，新冠肺炎对向人们提供护理服务产生了影响 感染艾滋病毒/艾滋病可能会逆转几十年来在护理和治疗方案方面取得的成果。数据 驱动型解决方案以及有针对性的研究和评估需要免费的领导团队，包括 生物统计学家。该地区缺乏博士级别的生物统计学家。 2017年，我们成功实施了艾滋病毒/艾滋病研究生物统计学硕士培养计划。 尽管缺乏受过高级培训的本地生物统计师，但我们动员国际合作者 协助教学和学生督导。为了我们培训计划的可持续性，自然 进步是培训当地未来的生物统计学领导人，他们将继续培训倡议，还 提供研究领导，以解决SSA的无数健康问题。 我们建议继续努力弥补SSA在生物统计能力方面的差距，并开展研究 斯泰伦博什大学和整个地区的领导力。这次更新的具体目标是 培训赠款将用于：(1)通过StellenBosch的博士培训方案发展生物统计学的领导力 大学；(2)继续通过硕士水平的学术方案建设生物统计能力，并扩大 我们使用电子学习平台覆盖的范围；(3)巩固ACBE在提供专业知识方面的领先地位 发展生物统计和数据管理，以支持艾滋病毒/艾滋病研究项目和方案 在SSA区域内，领导艾滋病毒/艾滋病和结核病研究活动。

PROJECT SUMMARY LMIC: South Africa Institution: Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town Scientific Area: Biostatistics for HIV/AIDS and TB research design and methodology Africa Center for Biostatistical Excellence: expanding biostatistical leadership for HIV/AIDS and TB research This application is in response to the FOA “Fogarty HIV Research Training Program for Low- and Middle- Income Country Institutions” under the D43 grant mechanism (FOA PAR-19-283) and requests 5 years of support to expand biostatistics leadership for HIV research design and methodology at Stellenbosch University in South Africa. HIV/AIDS and TB remain the highest contributors to the burden of disease in sub-Saharan Africa (SSA). The COVID-19 disease resulting from infection with the novel SARS-CoV-2 virus poses a threat to the fragile healthcare system and infrastructure in SSA. In particular, COVID-19 effects on the delivery of care to people living with HIV/AIDS is likely to reverse gains in care and treatment programs achieved over decades. Data driven solutions and targeted research and evaluations demand complimentary teams of leaders, including biostatisticians. There is a huge deficit of doctoral level biostatisticians in the region. In 2017, we successfully implemented a masters’ level training program in biostatistics for HIV/AIDS research. Despite shortage in local biostatisticians with advanced training, we mobilized international collaborators to assist with teaching and student supervision. For sustainability of our training program, the natural progression is to train local future leaders in biostatistics who will continue the training initiatives and also provide research leadership to address the myriad of health problems in SSA. We propose to continue our efforts to bridge the gap in biostatistics capacity in SSA and develop research leadership at Stellenbosch University and the region at large. The specific objectives of this renewal of the training grant are to: (1) develop biostatistics leadership through a doctoral training program at Stellenbosch University; (2) continue building biostatistics capacity through a Masters’ level academic program and expand our reach using e-learning platforms; (3) consolidate the ACBE as a leader in providing professional development in biostatistics and data management to support HIV/AIDS research projects and programs within the SSA region and lead HIV/AIDS and TB research activities.