BLOOD FLOW MONITORING TELEMETRY IMPLANT

在拟议的努力下，植入式遥测的可行性 用于清醒状态下慢性监测血容量流动的装置， 无拘无束的动物将被研究。这项努力的主要重点将是 是对几种行之有效的监测方法的评价 血流及其在植入性装置中的结合潜力 具有体积小、功耗低的特点。作为最低设计目标， 装置应能可靠地测量10%的相对流量 狗和非人类灵长类动物在一个位置的准确性持续了一段时间 至少350小时。该装置用于啮齿动物的改装是 次要目标。在项目期间，替代设计将是 首先从概念上调查，然后通过面包板模型进行调查。离体 测试将用于初步评估流量测量的准确性 另类设计。首选的设计将在体内进行评估，以 验证不同容器尺寸和流量下的流量测量结果。一个 还将对集成植入物进行需求分析 能够测量血流、血压、心率和心电图的变送器。 虽然目前还没有这样的设备可以商业使用，但最近 集成电路和电池技术的发展现在可能 让性价比高的设备变得可行。

Under the proposed effort, the feasibility of an implantable telemetry device for the chronic monitoring of blood volume flow in conscious, unrestrained animals will be studied. The main focus of this effort will be the evaluation of several well-established approaches to monitoring blood flow and their potential for incorporation in an implantable device with small size and low power consumption. As a minimum design goal, the device should be capable of reliably measuring relative flow with 10% accuracy at one site in dogs and non-human primates for a period of at least 350 hours. Adaptation of this device for application in rodents is a secondary goal. During the project alternate designs will be investigated, first conceptually and then via breadboard models. In vitro tests will be used to initially evaluate flow measurement accuracy of alternate designs. The preferred design will then be assessed in vivo to verify flow measurements on different vessels sizes and flow rates. A requirements analysis will also be conducted for an integrated implantable transmitter capable of measuring blood flow, pressure, heart rate and ECG. Although no such equipment is commercially available at present, recent developments in both integrated circuit and battery technology may now make a cost-effective device feasible.