RESEARCH IN CANCER EPIDEMIOLOGY AND BIOSTATISTICS

请求提供资金，以扩大 一项基于人群的黑人、白色人前列腺癌病例对照研究 和亚裔美国人进行了从10-1-89到8-31-94。 延长 将收集所有报告前列腺癌的受试者的癌症谱系数据， 一名或多名一级亲属患有癌症，以及随机抽取的 那些没有的人 目的是：i）比较病例和对照组， 考虑到先前报告的个人特征（饮食、身体状况）， 活动，身体大小），而分层的数量和类型的亲属 ii）比较观察到的部位特异性癌症 病例家庭中的发病率与区域发病率的预期值相符 率; iii）确定家族性前列腺癌模式是否提示 主要的易感基因，如果是这样，估计频率的一个或 这种基因的更有害的等位基因和年龄和种族特异性 携带者中的前列腺癌风险; iv）确定三个 或以上确诊的前列腺癌病例（包括先证者）， 一级或二级亲属，在这些家庭中， 与前列腺癌共分离的遗传标记， 易感基因的候选基因座。 实力 项目包括：1）详细的家庭历史，从同一个 黑人、白色和亚洲男性，他们之前提供了饮食、身体状况、 活动和身体大小，允许评估的综合影响， 前列腺癌的遗传易感性和生活方式特征 风险; 2）分离分析，如果支持主要易感因素 基因，将提供基于人群的基因频率估计， 3）约30-40个家系 与三个或三个以上的前列腺癌病例允许连锁分析， 确定易感基因，可以提供深入了解 所有前列腺癌的发展; 4）来自前列腺癌患者的库存血清和DNA 相同的高风险个体将允许未来比较类固醇 激素及其代谢产物在突变的携带者和非携带者 等位基因

Funds are requested to extend the San francisco component of a population-based case-control study of prostate cancer among black, white and Asian Americans conducted from 10-1-89 to 8-31-94. The extension will gather cancer pedigree data from all subjects who reported prostate cancer in one or more first-degree relatives, and a random sample of those who did not. Objectives are: i) to compare cases and controls with respect to previously reported personal characteristics (diet, physical activity, body size), while stratifying by number and type of relatives with-prostate cancer; ii) to compare observed site-specific cancer incidence in families of cases to that expected from regional incidence rates; iii) to determine if familial prostate cancer patterns suggest a major predisposing gene and if so, to estimate the frequency of one or more deleterious alleles of such a gene and the age- and race-specific prostate cancer risks among carriers; iv) to identify families with three or more confirmed prostate cancer cases (including the proband) among first- or second-degree relatives and within these families, to find genetic markers that co-segregate with prostate cancer and thus identify candidate loci for a predisposing gene or genes. Strengths of the project include: 1) detailed family histories, obtained from the same black, white and Asian men who previously provided data on diet, physical activity and body size, permit assessment of the combined effects of genetic susceptibility and lifestyle characteristics on prostate cancer risk; 2) segregation analysis, if supportive of a major predisposing gene, will provide population-based estimates of gene frequency and penetrance and their variation with age and race; 3) some 30-40 families with three or more cases of prostate cancer permit linkage analysis to identify predisposing genes that could provide insight into the development of all prostate cancers; 4) banked serum and DNA from the same high-risk individuals will allow future comparison of steroid hormones and their metabolites in carriers and non-carriers of mutated alleles.