Real-time neuronal network imaging using diamond optrode arrays

该项目旨在开发新的成像技术，以前所未有的分辨率和规模真实的时间记录细胞和神经元网络的电活动。这项技术创新源于金刚石中的一种光学缺陷，这种缺陷可以被设计成灵敏地检测电场的局部变化。全光学金刚石光极阵列器件将应用于生物模型系统，包括心肌细胞、哺乳动物细胞和神经元;并将以当前最先进的技术为基准。从高密度记录中获得的知识将有助于疾病的预测模型，并将导致对大脑微电路和功能连接体的更好理解。

The project aims to develop new imaging technology for real time recording of electrical activity from cell and neuronal networks with unprecedented resolution and scale. The technology innovation stems from an optical defect in diamond which can be engineered to sensitively detect local changes in electric field. The all-optical diamond optrode array devices will be applied to biological model systems including cardiomyocytes, mammalian cells, and neurons; and will be benchmarked against current state-of-the-art technologies. The knowledge gained from the high density recordings will aid predictive models of disease and will lead to an improved understanding of the brain’s micro circuity and functional connectome.