Understanding how the heart becomes more efficient

身体要求心脏以最高效率运转。小梁-心脏腔内的褶皱-使血液流动最大化，有助于腔室的发展并形成心脏的传导网络。小梁形成的问题引起心肌病和心律失常，但我们不了解其基本发展。该项目将研究这种组织形成身份的最早阶段，并检查指示小梁在心脏中形成所需的信号、遗传、细胞和细胞外线索。这项研究的发现将修订我们对小梁何时以及如何形成的理解，并提供有关如何生长和修复这一重要组织的关键信息。

The body demands that the heart function at utmost efficiency. Trabeculae – folds within the heart lumen – maximise blood flow, contribute to chamber development and form the electrical conduction network of the heart. Problems with trabeculae formation cause cardiomyopathy and arrhythmia and yet we do not understand its basic development. The project will investigate the earliest stages of when this tissue develops its identity and examine the signalling, genetic, cellular and extracellular cues required to instruct trabeculae to form in the heart. Findings from this research will revise our understanding of when and how trabeculae form and provide key information about how to grow and repair this important tissue.