A novel mechanism of host defence via macrophage extracellular traps

动物健康依赖于先天免疫细胞来快速检测入侵的微生物，并诱导炎症和抗菌反应来清除感染。人们对炎症和免疫防御的机制只有部分了解。这个项目旨在阐明一种新的先天免疫途径(炎症体)，它驱动炎性细胞死亡和抗菌防御。利用创新的多学科方法，该项目将产生关于炎症和抗微生物反应机制的令人兴奋的新知识，并为炎症肌肉作用提供新的范例。预期的成果和好处包括高影响力的出版物、国际合作、对年轻科学家的世界级培训，以及未来商业化的新知识。

Animal health relies upon innate immune cells to rapidly detect invading microbes and induce inflammatory and antimicrobial responses to clear infection. Mechanisms of inflammation and immune defence are only partly understood. This project aims to elucidate a novel innate immune pathway (the inflammasome) that drives inflammatory cell death and antimicrobial defence. Using innovative multidisciplinary methods, this project will yield exciting new knowledge of mechanisms of inflammation and anti-microbial responses, and new paradigms for inflammasome action. Expected outcomes and benefits include high-impact publications, international collaboration, world-class training for young scientists, and new knowledge for future commercialisation.