Mechanisms of memory function involving site-specific tau phosphorylation

这个项目旨在了解促进大脑中记忆编码，维持和检索的分子原理。为了在大脑回路中存储记忆，电信号和化学信号至关重要。脑细胞可以将信号整合到细胞内蛋白质的生化修饰中。脑细胞内代表记忆的蛋白质修饰的性质尚不清楚。该项目使用创新的基因组编辑，数学建模和蛋白质组学方法，研究一种名为tau的关键蛋白质的生化修饰如何帮助编码和检索记忆。这些分子见解将使目前对人类所有活动所必需的大脑功能的理解取得重大进展。

This project aims to understand the molecular principles that facilitate encoding, maintenance and retrieval of memories in the brain. To store memories in brain circuits, electrical and chemical signals are crucial. Brain cells can integrate signals into biochemical modifications of intracellular proteins. The nature of the protein modifications that represent memory within brain cells is unknown. This project uses innovative genome editing, mathematical modelling and proteomic approaches, to study how biochemical modifications of a key protein called tau help encode and retrieve memories. These molecular insights will make a significant advance in the current understanding of a brain function that is essential to all human activities.