Molecular probes for selective sensing of membrane phospholipids

该项目的目标是开发一种分子探针工具包，能够选择性地结合构成生物膜大部分的磷脂。细胞膜由一千多个结构不同的脂质分子组成，但我们还不清楚这些结构差异如何影响细胞功能。该项目将提供新的工具，可用于扩大我们对脂质多样性对生物功能影响的认识。这将巩固整个细胞生物学的进步。它将为合成化学家和细胞生物学家之间的跨学科合作提供新的机会。

The goal of this project is to develop a toolkit of molecular probes that are able to selectively bind to the phospholipids that constitute a large part of biological membranes. Membranes are composed of over one thousand structurally different lipid molecules but we do not have a clear understanding of how these structural differences impact on cell function. This project will provide new tools that can be applied to expand our knowledge of the impact of lipid diversity on biological function. This will underpin advances throughout cell biology. It will provide new opportunities for interdisciplinary collaboration between synthetic chemists and cell biologists.