STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目重点研究的是 调节氧与血红蛋白的结合和 将氧气输送到组织。重点放在 关于这些功能受损和改变的方式 随着年龄的增长。这些研究的重点是氧化 血红蛋白，产生无功能的血红蛋白和 氧自由基的同时释放。增强功能 在低氧条件下的这些氧化过程中 作为一种可能的组织和器官来源被探索 损伤，这将在老化过程中加剧。研究 也包括了针对稳定性的 整个红血球和红细胞膜。

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.