Genetic and Molecular Consequences of Non-Random Mating in Humans

本项目旨在开发和应用新颖的统计方法来量化人类两种非随机交配形式（近亲繁殖和分类交配）对大量复杂性状的影响。该提案的创新之处在于将多层次表型与从50多万研究参与者中收集的下一代测序数据整合在一起。本研究的预期结果包括先进的分析方法，以前所未有的表型细节尺度对人类非随机交配的生物学后果进行整合和解剖。这个项目的好处是找出可能导致经济、健康和社会不平等的配偶选择的新驱动因素。

This project aims to develop and apply novel statistical methods to quantify the effects on a large number of complex traits of two forms of non-random mating in humans, that is inbreeding and assortative mating. The innovation in this proposal lies in integrating multi-level phenotypes with next-generation sequencing data collected in more than half a million study participants. Expected outcomes of this research include advanced analytical methods to perform this integration and dissection of the biological consequences of non-random mating in humans at an unprecedented phenotypically detailed scale. The benefit of this project will be to identify new drivers of mate choice that can contribute to economic, health and social inequalities.