VISCERAL FAT METABOLIC RATE AND CHD RISK IN YOUNG ADULTS

在美国，肥胖症的患病率从 1960年的S到1980年的S，并因种族和性别而异，尤其是 黑人女性的肥胖率。造成中国民族差异的原因 肥胖症的流行情况还不清楚。这是一项关于 横断面研究将与10年期研究一起进行 青壮年冠状动脉危险发展的随访检查 成人(CARDIA)研究，一项由NHLBI资助的关于儿童发展的纵向研究 青年黑人和白人患冠心病的危险因素 成年人。我们建议通过以下方法测量内脏(腹内)脂肪 通过CT扫描和测量静息代谢率 400例28~40岁心源性心脏病患者的间接量热分析 种族/性别组)来自加利福尼亚州奥克兰和阿拉巴马州伯明翰 中锋。使用这些数据，我们将检验内脏的假设 脂肪组织，被认为与脂肪关系最密切的成分 对于CHD危险因素，黑人和白人受试者不同。具体来说，我们 建议黑人受试者的内脏脂肪组织将在 给定的身体总脂肪水平会比白人受试者高。此外， 内脏脂肪组织与冠心病危险因素的关系 所有科目都应该是相似的。这将解释不同的 黑白对比图显示肥胖与冠心病危险因素的关系 研究对象。第二个具体目标是确定黑人女性是否有 比黑人或白人更低的静息能量消耗。这可能会 解释为什么黑人女性的肥胖率高于黑人男性 也不是白人，无论男女。CT扫描将被记录在磁带上并发货 给科罗拉多大学健康科学中心，内脏脂肪 组织将被量化。饮食摄入量和体力活动将 代谢率之间关系中的重要协变量 和肥胖，以及甲状腺功能将被作为决定因素进行测量 静息能量消耗。CARDIA研究将为 心血管危险因素测量，包括血压、血脂、 胰岛素、血糖、吸烟和人体测量，包括 能量吸收法(DEXA)测量全身和局部脂肪。 这项研究代表了一个独特的机会来调查可能 影响肥胖的发展，更好地理解两者之间的关系 肥胖和心血管危险因素之间的关系，并增加 对肥胖的种族差异的理解。

The prevalence of obesity increased markedly in the United States from the l960's to the 1980's, and varies by race and gender with particularly high rates of obesity among black women. Reasons for the ethnic differences in the prevalence of obesity are not understood. This is a proposal for a cross-sectional study to be performed in conjunction with the 10-year follow-up examination for the Coronary Artery Risk Development in Young Adults (CARDIA) study, an NHLBI-funded longitudinal study of development of risk factors for coronary heart disease (CHD) in young black and white adults. We propose to measure visceral (intraabdominal) fat by computerized tomography (CT) scan and to measure resting metabolic rate by indirect calorimetry in 400 CARDIA subjects, ages 28-40 years (100 of each race/gender group) from the Oakland, California and Birmingham, Alabama centers. Using these data, we will test the hypothesis that visceral adipose tissue, the component of fat considered to be most strongly related to CHD risk factors, differs in black and white subjects. Specifically, we propose that black subjects will have less visceral adipose tissue for a given level of total body fat than will white subjects. Further, the relationship between visceral adipose tissue and risk factors for CHD should be similar in all subjects. This would explain the different relationship between obesity and CHD risk factors seen in black vs white subjects. A second specific aim is to determine whether black women have a lower resting energy expenditure than black men or whites. This could explain the higher prevalence of obesity in black women than in black men or whites of either gender. CT scans will be recorded on tape and shipped to the University of Colorado Health Sciences Center where visceral adipose tissue will be quantified. Dietary intake and physical activity will be measured as important covariates in the relationship between metabolic rate and adiposity, and thyroid function will be measured as a determinant of resting energy expenditure. The CARDIA study will provide funding for cardiovascular risk factor measurements, including blood pressure, lipids, insulin, glucose, smoking, and anthropometric measurements including dual energy absorptiometry (DEXA) measurements of total and regional body fat. This study represents a unique opportunity to investigate factors that may influence the development of obesity, to better understand the relationship between obesity and cardiovascular risk factors, and to increase understanding of racial differences in adiposity.