VALIDATION AND EXPLORATION OF SLEEP AND MOOD PREDICTORS

报告的短睡眠和长睡眠都是主要的预测因素 死亡风险过高，但将报告的睡眠时间作为风险输入 目前尚不清楚这一因素。与睡眠相关的风险特别令人感兴趣 妇女健康倡议(WHI)，因为女性失眠增加 在更年期，因为WHI的激素替代疗法(HRT)和 饮食调整(DM)可能会影响睡眠。WHI将是一个令人兴奋的 检查是否与报告的睡眠相关的风险的机会 持续时间可以通过选择并发条件来解释，但是 宽泛的WHI设计不会控制重要的潜在混杂因素。 显然，宽泛的WHI设计本身不能决定 行为可改变的客观睡眠时间是主要风险 因素。该辅助项目将补充WHI观测研究 (OS)对600名圣地亚哥OS妇女进行额外检查。 这些志愿者将接受家庭睡眠记录，荷尔蒙测量， 和详细的精神病学面谈。为了便于区分 情感和睡眠因素对WHI结果、类型和严重程度的影响 OS亚样本中的抑郁与睡眠的效度和可靠性 发放给WHI妇女的问卷第一项将被检查。辅助性的 研究将确定客观记录的睡眠持续时间是否 死亡危险因素，睡眠时间是否可以区分 在WHI数据中，抑郁是一个危险因素，以及睡眠相关的风险 可归因于特定的病理生理过程，如睡眠 呼吸暂停，昼夜节律相提前，褪黑激素缺乏，或 褪黑素缺乏或生殖类固醇缺乏。

Both reported short sleep and reported long sleep are major predictors of excess mortality risk, but the import of reported sleep duration as a risk factor is not yet known. Sleep-related risks are of special interest to The Women's Health Initiative (WHI), because insomnia increases among women at menopause, and because WHI's hormone replacement therapy (HRT) and dietary modification (DM) may influence sleep. The WHI will be an exciting opportunity to examine whether risks associated with reported sleep durations can be explained by a selection of intercurrent conditions, but the broad WHI design will not control for important potential confounders. Explicitly, the broad WHI design by itself cannot determine if behaviorally-modifiable objective sleep durations are the primary risk factor. This ancillary project will supplement th WHI Observational Study (OS) by performing additional examinations on 600 San Diego OS women. These volunteers will undergo home sleep recordings, hormone measurement, and detailed psychiatric interviews. To facilitate distinction of affective and sleep factors in WHI outcomes, the types and severity of depression in the OS subsample and the validity and reliability of sleep items i questionnaires given to WHI women will be examined. The ancillary studies will determine whether objectively recorded sleep durations are mortality risk factors, whether sleep duration can be distinguished from depression as a risk factor in WHI data, and whether sleep-associated risks are attributable to specific pathophysiologic processes such as sleep apnea, circadian rhythm phase advances, deficiencies of melatonin, or deficiencies of melatonin, or deficiencies of reproductive steroids.