NEUROTOXICOLOGY OF SUPERFUND CHEMICALS

本申请是为响应RFA ES-91-02而准备的，将解决 需要对精神分裂症的神经和行为方面进行更多的研究 超级基金垃圾场中常见的化学物质。国内的研究重点 该计划的八个多学科项目将在 具体解决选定溶剂的神经毒性问题 三氯乙烯，一氯乙酸，相关卤化 碳氢化合物)和金属(铅)。设计这些项目的目的是检查： 1.溶剂的水文地质。 2.生物化学/细胞水平上的溶剂神经毒性。 3.铅对发育中和成年神经系统的神经毒性。 4.对铅和溶剂的生态和人类神经行为反应。 5.超级基金生物处理的工程方法 污染物。 这些研究将由环境和环境保护局成员进行 职业健康科学研究所，一个研究机构，包括 罗格斯大学、新泽西州立大学和R.W.的调查人员。 纽约医科大学约翰逊医学院 泽西岛。

This application, prepared in response to RFA ES-91-02, will address the need for additional studies on neurological and behavioral aspects of chemicals commonly found in Superfund dumpsites. Research focus within the eight multidisciplinary projects of the program will be achieved by addressing specifically the neurotoxicity of selected solvents (trichloroethylene, monochloroacetic acid, related halogenated hydrocarbons) and metals (lead). Projects have been designed to examine: 1. the hydrogeology of solvents. 2. the neurotoxicity of solvents at the biochemical/cellular levels. 3. the neurotoxicity of lead on developing and adult neuronal systems. 4. the ecological and human neurobehavioral responses to lead and solvents. 5. engineering approaches to the biological treatment of Superfund contaminants. These studies will be conducted by members of the Environmental and Occupational Health Sciences Institute, a research institute comprising investigators from Rutgers, The State University of New Jersey and R.W. Johnson Medical School, The University of Medicine and Dentistry of New Jersey.