A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions

该项目旨在通过开发一种微生物-肠道共培养芯片来模拟肠道微生物与器官的相互作用，该芯片可以与其他芯片上的器官可逆地接口。这是通过高度可定制的生物制造和微流控技术的系统集成实现的。该项目填补了可用于研究微生物组-宿主相互作用的动物替代系统的关键技术空白，这将极大地补充现有的荟萃组学方法。交付成果包括对肠道-肝脏轴进行验证的概念验证系统，以及创造新的知识和框架以吸收设计思维和先进制造，将组织工程提升为生理工程。

This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering.