COMPUTATIONAL ASPECTS OF PRIMATE MEMORY

总体目标是更好地理解记忆 大脑的系统和功能。这个项目的目的是澄清 短时激活记忆在大鼠神经网络中的作用机制 大脑皮层。这个问题很重要，因为活动记忆是 对有效控制顺序行为和更高级别至关重要 在某些精神疾病中普遍存在的认知功能 精神障碍，特别是精神分裂症。拟议的研究基本上是 并具有两个紧密交织的组件：(A) 大脑皮质神经细胞在记忆中的放电分析 (B)开发大脑皮层记忆的计算机模拟模型。这个 反复激活神经元在记忆中的作用将被研究 通过对单机尖峰放电模式和单机尖峰放电模式的分析，提出了单机尖峰放电的数学模型 多个同时记录的单元。前额叶皮质在脑内的作用 记忆将通过研究冷却大脑皮层的效果来检验 对壁细胞和触觉记忆性能的影响。由此产生的经验 模型将被用作以下假设的经验性检验的来源 活动记忆中的皮质网络动力学。

The overall objective is to gain better understanding of the memory systems and functions of the brain. This project is designed to clarify the mechanisms of temporary active memory in neuronal networks of the cerebral cortex. The question is important because active memory is essential for effective control of sequential behaviors and higher cognitive functions which are commonly deranged in certain mental disorders, notably schizophrenia. The proposed research is basically computational and has two closely intertwined components: (a) the analysis of electrical discharge of cortical nerve cells in memory; and (b) the development of computer simulation models of cortical memory. The role of recurrent activation of neurons in memory will be investigated by analysis of the patterns of spike discharge in single units and in multiple simultaneously recorded units. The role of prefrontal cortex in memory will be examined by studying the effects of cooling that cortex on parietal cells and on tactile memory performance. Resulting empirical models will be used as the source of empirically testable hypotheses of cortical network dynamics in active memory.