Mathematical models of 4D multicellular spheroids

数学模型在提供生物学洞察力方面有着悠久而成功的历史，必须开发新的数学模型来跟上新兴技术的步伐。现代的实验程序包括研究带有荧光标记的3D多细胞球体，以显示细胞的位置和细胞周期的进展。这种4D数据(3D空间信息+细胞周期时间)提供了大量信息。目前还没有专门开发的数学模型来解释/预测4D球体。该项目将提供第一个高保真的数学模型来实时解释/预测4D球体实验，提供对内在机制和对各种干预治疗的反应的定量洞察。

Mathematical models have a long, successful history of providing biological insight, and new mathematical models must be developed to keep pace with emerging technologies. Modern experimental procedures involve studying 3D multicellular spheroids with fluorescent labels to show both the location of cells and the cell cycle progression. This 4D data (3D spatial information + cell cycle time) provides vast information. No mathematical models have been specifically developed to interpret/predict 4D spheroids. This project will deliver the first high-fidelity mathematical models to interpret/predict 4D spheroid experiments in real time, providing quantitative insight into innate mechanisms and responses to various intervention treatments.