MODULATION OF SOMATOSENSORY TRANSMISSION DURING MOVEMENT

这项研究解决了定义神经回路的必要性 大脑处理不同类型躯体感觉的机制 实际行为情况下的感觉信息，尤其是在 四肢的活跃运动。作为一个例子，PI描述了 躯体感觉传入初级躯体感觉的一种现象 大鼠的大脑皮质根据触觉的不同阶段而改变 前肢的动作。在这一点上，皮肤感觉输入来自 前爪投射到特定类别的皮质神经元的门控或 门控-根据刺激是否在禁食期间提供 肢体朝向目标的移动，或在触摸目标期间 它本身。这些研究将继续确定 感觉门控发生的躯体感觉系统，在 前肢自发或可操作的条件性运动的背景 或者胡须。运动皮质和其他偏见可能起到的作用 消息人士可能会在这一现象中发挥作用，也将加以考察。新技术 用于记录多个单一单元的多个CNS级别将是 受雇于这些研究。

This investigation addresses the need to define the neural circuit mechanisms by which the brain processes different types of somesthetic sensory information during actual behavioral situations, especially during active movements of the limbs. As an example of this, the PI has described a phenomenon in which somatic sensory input to the primary somatosensory cortex of the rat is modified according to the phases of reach-to-touch movements of the forelimb. In this, cutaneous sensory inputs from the forepaw projecting to specific classes of cortical neurons are gated-in or gated-out according to whether the stimulation is delivered during the fast movement of the limb toward a target, or during the touch of the target itself. These studies will continue to define the sites in the somatosensory system at which this sensory gating is occurring, in the context of spontaneous or operantly conditioned movements of the forelimb or the whiskers. The possible role that the motor cortex and other biasing sources may play in this phenomenon will also be examined. New techniques for recording multiple single units at multiple levels of the CNS will be employed in these studies.