IMAGE SURFACE SENSOR ARRAY FOR BIOMAGNETIC MEASUREMENTS

目前的建议是建立、测试和实施一个新的 用于神经磁测量的生物磁传感器阵列的概念 基础研究和临床应用。 神经磁性是一种 越来越有用的方法来研究这些领域的神经源。 的 一种较便宜的传感器阵列可以大大增强这一点 使用. 这个新概念，它依赖于使用超导图像 表面，以提供梯度仪响应从单一线圈，有一些 与现有的生物磁传感器阵列设计相比具有明显的优点。 这些 优点是：（1）传感器线圈的大阵列的构造， 在成像表面梯度仪设计中比标准的 轴向梯度仪方法，导致潜在的显着减少 （2）由于数量较少， （3）神经源所产生的能量; 超导图像表面，呈半球壳的形状， 对外场产生很大的屏蔽效应， 与梯度仪的行动，大大减少了需要一个 昂贵的屏蔽室;（4）组装的阵列体积小于 垂直轴向梯度仪阵列。 超导像面 梯度计概念已在实验室得到验证， 进行理论计算，以确定其有效性， 各种条件。 目标是构建一个由93个传感器组成的大型阵列 其将同时覆盖头部的大约120度。 新的轴向梯度计不需要93个精确缠绕的轴向梯度计， 这项技术只需要一个半球帽， 超导表面沉积在一侧和一组93个线圈 放在另一个。 每个线圈都连接到SQUID，以提供 磁通-电压转换 该阵列将分阶段构建， 用7个SQUID，然后逐渐扩大数组。 这一系列的 传感器最初将在洛斯阿拉莫斯神经科学计划中进行测试。 随后的临床试验将在阿尔伯克基VA进行 这是洛斯阿拉莫斯-弗吉尼亚州-新墨西哥大学合作的生物磁设施。 的 对从这个大阵列获得的数据的分析将通过以下方式进行： 新开发的时空方法在洛斯阿拉莫斯，以及新的 计算神经元位置和性质的理论方法 源

The present proposal is to construct, test and put into practice a new concept in biomagnetic sensor arrays for neuromagnetic measurements for both basic research and clinical applications. Neuromagnetism is an increasingly useful method for studying neural sources in these areas. The proposed, less expensive array of sensors could substantially augment this usage. This new concept, which relies on the use of super-conducting image surfaces to provide gradiometer response from single coils, has a number of distinct advantages over existing biomagnetic sensor array designs. These advantages are: (1) the construction of a large array of sensor coils is much simpler in the imaging surface gradiometer design than with standard axial gradiometer methods, resulting in a potential significant reduction in cost; (2) there is increased sensitivity due to a smaller number of coils required to share the energy generated by neural sources; (3) the superconducting image surface, in the shape of a hemispherical shell, produces a large screening effect on external fields which, when combined with the gradiometer action, significantly reduces the need for an expensive shielded room; and (4) the assembled array is less bulky than an array of normal axial gradiometers. The super-conducting image surface gradiometer concept has been verified in the laboratory and extensive theoretical calculations carried out to ascertain its effectiveness under various conditions. The goal is to construct a large array of 93 sensors which would cover approximately 120 degrees of the head simultaneously. Instead of requiring 93 accurately wound axial gradiometers, the new technique would require only a single hemispheric cap with a superconducting surface deposited on one side and a set of 93 coils deposited on the other. Each coil is connected to a SQUID to provide the flux-to-voltage conversion. The array will be built in stages starting with 7 SQUIDs and then gradually enlarging the array. This large array of sensors would be tested initially in the Los Alamos neuroscience program. Subsequent clinical trials would be carried out at the Albuquerque VA biomagnetic facility which is a Los Alamos - VA - UNM collaboration. The analysis of data obtained from this large array would be carried out by newly developed spatial-temporal methods at Los Alamos, as well as new theoretical methods in calculating the location and nature of neural sources.