A Biomagnetic Sensor for Detecting Breast Cancer

用于检测乳腺癌的生物磁传感器

• 批准号: 7493961
• 负责人: EDWARD R FLYNN
• 金额: $ 60.78万
• 依托单位: SENIOR SCIENTIFIC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-29 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493961
• 关键词: Adopted; Algorithms; Animals; Antibodies; Antineoplastic Agents; Benign; Binding; Biological; Biopsy; Body Weight; Breast; Cancer Detection; Cancerous; Caring; Categories; Cells; Centrifugation; Characteristics; Cicatrix; Clinical; Conjugating Agent; Contrast Media; Data; Dependence; Depth; Detection; Development; Device or Instrument Development; ERBB2 gene; Early Diagnosis; Environment; Frequencies; Goals; Growth; Guidelines; Heating; Histology; Housing; Human; Image; Imaging Techniques; Injection of therapeutic agent; Investigation; Knowledge; Lesion; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Mammary Neoplasms; Mammography; Maps; Measurement; Measures; Methodology; Methods; Modeling; Mus; Neoplasm Metastasis; Numbers; Patients; Personal Satisfaction; Phase; Phase I Clinical Trials; Physiologic pulse; Pliability; Principal Investigator; Property; Protein Overexpression; Pulse taking; Radiation; Radiation therapy; Radio; Radionuclide Imaging; Range; Rate; Research; Research Personnel; Resolution; Sentinel; Sentinel Lymph Node; Signal Transduction; Simulate; Site; Solutions; Source; Specificity; Squid; Standards of Weights and Measures; Structure; System; Techniques; Testing; Time; Tissues; Tumor Tissue; Ultrasonography; angiogenesis; base; biological research; breast lesion; cancer cell; cancer imaging; cancer site; cancer type; density; design; design and construction; improved; in vivo; instrumentation; magnetic field; malignant breast neoplasm; mouse model; nanoparticle; novel strategies; particle; programs; receptor; research and development; research study; response; sensor; size; small molecule; software development; success; superconducting quantum interference device; tissue phantom; tissue preparation; tumor

DESCRIPTION (provided by applicant): The principal objective of this application is to establish a new methodology for the early detection of abnormal lesions, whether pre-cancerous or cancerous, in breast imaging. Early detection is crucial to identifying lesions while they are still contained when the cure rate is near 100%. Existing mammography often does not identify lesions until significant growth has occurred. Because of the importance of the problem, there is research in alternative methods, including MRI, ultrasound, scintigraphy, and other methods. We propose here, a novel approach using biomagnetic sensors and targeted superparamagnetic nanoparticles. The sensor will detect and image lesions in-vivo to which these particles have bound by antibodies or angiogenesis agents after injection into the subject. We have demonstrated in Phase I of this program, that Superconducting Quantum Interference Devices (SQUID) are capable of detecting sub- nanograms of these nanoparticles. This methodology has advantages over existing mammography in the flexibility of nanoparticle choices to increase specificity through antibodies targeting cancer types such as HER-2, and angiogenesis agents targeting tumor microvascular structure. Nanoparticles will also be used to image sentinel cells for metastases. We will use phantoms and tissue preparations to characterize nanoparticles for sensitivity and image capabilities and animal studies to verify the methodology. We will further affirm imaging accuracy through the use of these nanoparticles as contrast agents in MRI studies in our animal studies. We anticipate that the detection of lesions by magnetic sensors will provide a lower false positive rate than mammograms and, more importantly, a higher true positive rate.

描述（由申请人提供）：本申请的主要目的是建立一种在乳腺成像中早期发现异常病变的新方法，无论是癌前还是癌性。早期检测对于鉴定病变时仍包含在100％的治疗速率时仍包含病变至关重要。现有的乳腺X线摄影通常不会识别出病变，直到发生显着增长。由于该问题的重要性，因此有替代方法的研究，包括MRI，超声，闪烁图和其他方法。我们在这里提出了一种使用生物磁传感器和靶向超磁纳米颗粒的新型方法。传感器将检测和图像病变在体内，这些颗粒在注射到受试者后受抗体或血管生成剂的约束。我们已经在该程序的第一阶段证明了，超导量子干扰装置（Squid）能够检测这些纳米颗粒的亚纳米图。该方法比现有乳房X线摄影具有优势，在纳米颗粒选择的灵活性方面，通过针对癌症类型（例如HER-2）和靶向肿瘤微血管结构的血管生成剂来提高特异性。纳米颗粒也将用于对前哨细胞进行转移图像。我们将使用幻像和组织制剂来表征纳米颗粒的灵敏度和图像能力以及动物研究以验证方法。我们将通过将这些纳米颗粒作为动物研究中MRI研究中的对比剂来进一步肯定成像准确性。我们预计，磁性传感器对病变的检测将比乳房X线照片提供较低的假阳性率，更重要的是，真正的正效率更高。

项目成果

Characterization of magnetite nanoparticles for SQUID-relaxometry and magnetic needle biopsy.

• DOI: 10.1016/j.jmmm.2009.02.067
• 发表时间: 2009-05-01
• 期刊: Journal of magnetism and magnetic materials
• 影响因子: 2.7
• 作者: Adolphi NL;Huber DL;Jaetao JE;Bryant HC;Lovato DM;Fegan DL;Venturini EL;Monson TC;Tessier TE;Hathaway HJ;Bergemann C;Larson RS;Flynn ER
• 通讯作者: Flynn ER