Improving Biopsies using Magnetic Nanoparticles

使用磁性纳米颗粒改善活检

基本信息

批准号：
7477619
负责人：
EDWARD R FLYNN
金额：
$ 33.47万
依托单位：
SENIOR SCIENTIFIC
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-20 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7477619
关键词：
Acute Lymphocytic Leukemia Acute Promyelocytic Leukemia Adjuvant Therapy Adopted Antibodies Antineoplastic Agents Applications Grants Area Aspirate substance Binding Biochemical Biocompatible Biological Biological Markers Biopsy Blood Tests Blood Vessels Blood specimen Bone Marrow Bone Marrow Involvement Bone marrow biopsy Breast Cancerous Cells Characteristics Child Chronic Myeloid Leukemia Clinical Clinical Trials Collecting Cell Collection Condition Cytometry Data Detection Development Disease Drug usage Dysmyelopoietic Syndromes Europe Excision Future Goals Heating Hodgkin Disease Human Human body Label Lead Left Life Lymphoma Magnetism Malignant Neoplasms Marrow Measurement Measures Metals Methodology Methods Microscopic Molecular Profiling Monitor Nanostructures Nanotechnology Nature Needle biopsy procedure Needles Numbers Ovarian Pain Patient Monitoring Patients Personal Satisfaction Phase Plastics Procedures Process Property Prostate Public Health Randomized Range Reporting Research Ethics Committees Residual Neoplasm Residual Tumors Sampling Sensitivity and Specificity Site Specificity Squid Staging Standards of Weights and Measures T-Cell Leukemia Techniques Testing Therapeutic Therapeutic Agents Therapeutic Intervention Time Tissues Woman angiogenesis base bcr-abl Fusion Proteins bone cancer cell cancer site cancer type cell type chemotherapy clinical application controlled release design experience hyperthermia treatment improved leukemia magnetic field malignant breast neoplasm millisecond movie nanoparticle nanosystems novel older patient outcome forecast particle peripheral blood prognostic programs radius bone structure sensor size tool

项目摘要

DESCRIPTION (provided by applicant): In children with acute lymphomatic leukemia (ALL) and in myelodysplastic syndrome (MDS) with older patients it is extremely important to measure the minimal residual disease (MRD) to monitor the progress of chemotherapy at early stages Such measurements determine the prognosis, efficacy, and levels of the treatment. The normal method for detection and monitoring is through bone marrow biopsies. Unfortunately, this method requires multiple biopsies to obtain sufficient samples and these must be made at periodic intervals to monitor the treatment. It is possible to substantially improve the efficiency of biopsies through the use of appropriately labeled magnetic nanoparticles and using magnetic collection methods. These antibody-labeled magnetic nanoparticles seek out, and attach themselves to, cancer cells, which can then be collected magnetically. This grant application describes the methodology behind this biopsy technique using a }smart} magnetic biopsy needle making it possible to substantially increase the efficiency of the biopsy as well as the specificity for particular leukemia cancer types but also including the sampling of metastatic rare cancer cells in the marrow. By using magnetic nanoparticles coated with anti-cancer agents and magnetically concentrated, direct therapeutic intervention at the cancer site is possible. PUBLIC HEALTH RELEVANCE: Nanotechnology for Disease Detection, Magnetic Nanoparticles for targeting Disease, Magnetic Needle for Bone Marrow Biopsy

描述（由申请人提供）：在患有急性淋巴白血病（全部）的儿童中以及与老年患者的骨髓塑性综合征（MDS）中，测量最小的残留疾病（MRD）非常重要，以监测早期阶段化学疗法的进展，例如早期的测量结果决定了治疗的预后，疗效和治疗水平。检测和监测的正常方法是通过骨髓活检。不幸的是，此方法需要多个活检才能获得足够的样本，必须定期进行这些样本以监测治疗。通过使用适当标记的磁性纳米颗粒并使用磁收集方法，可以实质上提高活检的效率。这些抗体标记的磁性纳米颗粒会寻找并将其固定在癌细胞上，然后可以磁性地收集。该赠款应用使用A} smart}磁性活检针头描述了这种活检技术背后的方法，从而可以实质上提高活检的效率以及特定白血病癌症类型的特异性，但还包括对骨髓中转移性稀有癌细胞的取样。通过使用覆盖有抗癌药物的磁性纳米颗粒并磁浓缩，可以在癌症部位进行直接治疗干预。公共卫生相关性：用于疾病检测的纳米技术，用于靶向疾病的磁性纳米颗粒，用于骨髓活检的磁针