BEHAVIORAL/LIGHT EFFECTS ON MENSTRUAL CYCLE REGULATION

描述（改编自申请人的摘要）：这是一个小补助金 建议测试精神病/行为治疗的新方法。 先前 埃德蒙·迪万和加州大学圣地亚哥分校的研究表明， 光可以缩短和调节月经周期的妇女长 月经周期不规律 可能会出现一些月经不调 从女性如何将自己暴露在明亮和 昏暗的照明。 进一步测试新的夜间照明方法， 技术是必要的，以进一步验证治疗方法， 定时（在每月和夜间的时间），以延长 剂量/反应测试，并进一步评估舒适性和可靠性 睡眠面具 60名受薪女性志愿者， 35-60天将被招募。 将前瞻性随访每例受试者 然后随机分配至夜间照明组 在月经开始后的第13-17天晚上进行治疗。 治疗 通过分层随机化分配，将由250个通量白色灯组成 （先前证明有效的治疗）、25 lux、2.5 lux或 0.025勒克斯（安慰剂）。 在接下来的两个月经周期中， 将增加交叉治疗。 如果受试者对第一个 在第二个和第三个治疗周期中重复。 如果受试者在第一个或第二个周期中没有反应， 加大治疗力度。 如果一个可靠的方法， 调节月经周期与夜灯可以证明，这 方法可能会导致有价值的方法，协助行为（节奏） 避孕和治疗不孕症的新方法。

DESCRIPTION (Adapted from the Applicant's Abstract): This is a small grant proposal to test new methods of psychiatric/behavioral treatment. Previous research by Edmond Dewan and by this UCSD group has suggested that night light can shorten and regularize the menstrual cycles of women with long and irregular menstrual cycles. Some menstrual irregularities may arise from behavioral aberrations in how women expose themselves to bright and dim illumination. Further testing of new night light methods and techniques is necessary to further validate the treatment methods and timing (in terms of both time-of-the-month and time-of-night), to extend dose/response testing, and to further assess the comfort and reliability of lighted sleep masks. Sixty paid female volunteers with menstrual cycles of 35-60 days will be recruited. Each subject will be followed prospectively for a baseline menstrual cycle, and then will be randomized to night light treatment on nights 13-17 after the onset of menstruation. Treatments assigned by stratified randomization will consist of 250 flux white light (a treatment previously demonstrated to be effective), 25 lux, 2.5 lux, or 0.025 lux (a placebo). In the following two menstrual cycles, conditional crossover treatments will be added. If the subject responds to the first treatment, it will be repeated in the second and third treatment cycles. If the subject fails to respond in the first or second cycles, the treatment intensity will be stepped-up. If a reliable methodology of regulating menstrual cycles with night lights can be demonstrated, this approach might lead to valuable methods of assisting behavioral (rhythm) contraception and to new approaches to infertility.