GORDON RESEARCH CONFERENCE ON INTERMEDIATE FILAMENTS

这项提议的目的是为了筹集资金支持旅行， 戈登研究所参与者的注册和生存 中长丝会议将于1994年7月24日至29日举行 在新罕布夏州蒂尔顿的蒂尔顿学校。 中间纤维(IF)是纤维的重要组成部分。 大多数真核细胞的细胞骨架和核骨架，以及虚拟的 填充终末分化的表皮角质形成细胞的细胞质 脊椎动物和无脊椎动物神经元的轴突。中间人 丝蛋白(IF)基因家族包括五个不同的类别，分别是 以组织特异性的方式表达。尽管存在这种异质性，但如果 直径(8-10 nm)和体外组装时的结构外观 无论组织来源如何，都非常相似。迭代函数系统的异构性 提示了这类多肽的细胞类型特异性功能。 阐明这些功能一直是研究人员面临的主要挑战 这些年来。然而，最近的发现是IF基因的突变 可导致人类疾病突出了IF网络在 保持组织完整性，并将这一领域带入了令人兴奋的 新时代。 这次会议将汇聚国际领域的与会者 来自学术界和工业界的人士在有利于自由的氛围中 思想交流。待开发的主题包括：1)演变 如果基因及其在发育中的作用，2)结构，组装和 IF和核层的动力学，3)IF-细胞表面相互作用，4) 植物和低等生物中IFs的同系物和类似物，5) IFs参与与癌症相关的病理和疾病，6)a 同源重组技术研讨会，7)皮肤病 角蛋白；8)IF与神经系统疾病的关系。如中所示 往年，将有非正式的海报展示和一次会议 致力于讨论精选的海报，包括获奖海报 今年将举行的青年科学家竞赛的参赛作品。

The purpose of this proposal is to generate funds to support the travel, registration and subsistence for participants in the Gordon Research Conference on Intermediate Filaments, which will be held July 24-29, 1994 at the Tilton School, Tilton, New Hampshire. Intermediate filaments (IFs) are prominent constituents of the cytoskeleton and karyoskeleton of most eukaryotic cells, and virtually fill the cytoplasm of terminally differentiating epidermal keratinocytes and the axons of vertebrate and invertebrate neurons. The intermediate filament (IF) gene family comprises five different categories which are expressed in a tissue specific manner. In spite of this heterogeneity, IF diameter (8-10nm) and structural appearance upon assembly in vitro is quite similar regardless of the tissue source. The heterogeneity of IFs suggests a cell type specific function for this class of polypeptides. Elucidating these functions has been a major challenge for researchers over the years. However, the recent discovery that mutations in IF genes can lead to human disease highlights the importance of the IF network in maintaining tissue integrity, and has ushered this field into an exciting new era. This conference will bring together an international field of participants from both academia and industry in an atmosphere conducive to the free exchange of ideas. Themes to be developed include: 1) the evolution of IF genes and their role in development, 2) the structure, assembly and dynamics of IFs and nuclear lamins, 3) IF-cell surface interactions, 4) homologues and analogues of IFs in plants and lower organisms, 5) the involvement of IFs in pathology and disease as related to cancer, 6) a workshop on homologous recombination technology, 7) epidermal diseases of keratin, and 8) the involvement of IFs in neurological diseases. As in previous years, there will be informal poster presentations and a session dedicated to the discussion of selected posters, including the winning entries in a young scientist competition to be instituted this year.