CHEMICAL DISPOSITION

这个项目的目的是“化学处置的研究” 哺乳动物“，目的是促使化学处置研究在 支持本局进行的毒性及致癌研究 国家毒理学计划(NTP)。该计划旨在提供 关于接触以下物质可能造成的急性和慢性毒性的数据 精选的化学品。承包商应进行6-10次化学处理 以及每年的毒物动力学研究。这些研究的结果提供了 预测生物累积和毒性的基础，从而 提高剂量选择的准确性，改进设计 动物生物检测程序。此外，化学处置和 毒代动力学研究提供的信息将使NTP能够 建立毒性和生物利用度之间的关系 化学物质和/或代谢物，并允许更好地推断 把实验室数据传给人类。根据这一项目获得的合同将 根据前身合同N01ES65137和N01ES65138继续工作。

The purpose of this project, entitled "Studies of Chemical Disposition in Mammals", is to procure chemical disposition studies to be performed in support of the toxicity and carcinogenicity studies conducted by the National toxicology Program (NTP). This program is designed to provide data on acute and chronic toxicity which may result from exposure to selected chemicals. The Contractor shall conduct 6-10 chemical disposition and toxicokinetic studies per year. The results of these studies provide the basis for predictions of bioaccumulation and toxicity and thereby enhance the accuracy of dose selection as well as improve the design of the animal bioassay program. Furthermore, chemical disposition and toxicokinetic studies provide information which will allow the NTP to establish the relationships between toxicity and bioavailability of chemicals and/or metabolites and permits a better extrapolation of laboratory data to humans. The contracts obtained under this project will continue the work under predecessor contracts N01ES65137 and N01ES65138.