TOXICOLOGY OF AIDS THERAPEUTICS

合同的目的是进行多达六项的毒性研究。 在啮齿类动物中持续时间为3个月。 这些研究应根据以下要求进行： 工作总说明书的程序和要求， 系统毒性分支和研究方案， 治疗学 这些研究应：1）提供艾滋病筛查 单独或组合给予大鼠和/或小鼠的治疗剂，用于 一般、生殖/发育和其他系统特异性毒性， 和2）提供研究一般毒性发展的机制 在单独或联合施用AIDS治疗剂的大鼠和小鼠中， 在很长一段时间内。 应执行以下任务： 任务Ia：啮齿动物生殖/生殖一般毒性研究 暴露于单一治疗药物或联合治疗药物。 任务Ib：暴露于单一治疗药物的啮齿动物28天毒性研究 或治疗的组合。 任务II：啮齿动物暴露于单次 治疗剂或治疗剂的组合。 任务III：啮齿动物暴露于单一药剂或 一个代理人的组合。

The purpose of the Contract is to conduct toxicity studies of up to six months duration in rodents. These studies shall be conducted according to the procedures and requirements of the General Statement of Work for the Systems Toxicity Branch and study protocols developed for specific therapeutics. Such studies shall 1) provide a screen for AIDS therapeutics, administered alone or in combination to rats and/or mice, for general, reproductive/developmental, and other systems-specific toxicities, and 2) provide a mechanism to study the development of general toxicities in rats and mice administered AIDS therapeutics, alone or in combination, over an extended period of time. The following tasks shall be performed: TASK Ia: REPRODUCTIVE/DEVELOPMENTAL GENERAL TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC AGENT OR A COMBINATION OF THERAPEUTICS. TASK Ib: 28-DAY TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC OR A COMBINATION OF THERAPEUTICS. TASK II: 13-WEEK (90-DAY) TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC OR A COMBINATION OF THERAPEUTICS. TASK III: 6-MONTH TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE AGENT OR A COMBINATION OF AGENTS.