PRECHRONIC AND CHRONIC STUDIES OF GLYOXAL

这些研究将表征其毒性和致癌潜力。 F344、大鼠和B6C3F1小鼠暴露于乙二醛 喝水。慢性前期毒性将通过给药进行评估 乙二醛在五种不同浓度下连续13周。在结束时， 研究器官的重量将被确定，所有动物都将收到 完成大体检查。所有组织的组织病理学评价 大体损伤和靶器官的检查将会完成。 乙二醛的致癌潜力将通过给药进行评估 三种不同浓度乙二醛对F344大鼠饮水的影响 和B6C3F1小鼠2年。在研究结束时，所有动物都将 接受完整的大体检查，所有组织都将保存固定，并 幻灯片制作完成。高剂量和高剂量照射后所有组织的组织病理学评价 对照动物和靶组织中的低剂量动物将 指挥。

These studies will characterize the toxicity and carcinogenic potential F344, rats and B6C3F1 mice associated with exposure to glyoxal in the drinking water. Prechronic toxicity will be evaluated by administering glyoxal at five different concentrations for 13 weeks. At the end of the study organ weights will be determined and all animals will receive a complete gross examination. Histopathological evaluation of all tissues with gross lesions and of target organs will be done. The carcinogenic potential of glyoxal will be evaluated by administering glyoxal at three different concentrations in drinking water to F344 rats and B6C3F1 mice for 2 years. At the end of the study all animals will receive a complete gross examination, all tissues will be saved fixed, and slides made. Histopathologic evaluation of all tissues in high dose and control animals and in target tissues in lower dose animals will be conducted.