CLINICAL TRIALS CENTER FOR ALLHAT

该计划的目的是进行一项基于实践的随机 抗高血压药物治疗的临床试验， 40，000例高危高血压患者中的特定亚组，降脂 包括至少55%的非洲裔美国人。 的目的 抗高血压试验是为了确定 致死性冠心病（CHD））和非致死性心肌梗死 利尿剂治疗和三种替代抗高血压药物之间的差异 药物治疗：钙拮抗剂，血管紧张素转换酶 酶（ACL）抑制剂和α肾上腺素能阻滞剂。 降胆固醇成分的目的是确定 降低中度高胆固醇血症男性的血清胆固醇， 60岁及以上女性，3-羟甲基戊二酰辅酶A (HMG辅酶A）还原酶抑制剂将降低致死性 CHD和非致死性心肌梗死。 包括胆固醇- 降低组分取决于获得HMG-CoA还原酶 抑制剂，目前尚未最终确定。 核准着手 降脂试验将不会被授予，直到可用性 这个探员的身份已经得到保护 与其使用独立资助的诊所， 通过以办公室为基础的做法和高血压诊所， 由临床试验中心（CTC）按每例患者报销。 本合同适用于临床试验中心。 的一些功能 临床试验中心包括协调所有数据收集， 数据存储、与研究相关的分析活动和招募 和培训（沿着NHLBI）适当的临床研究中心和核心 实验室需要进行研究。

The purpose of this program is to conduct a practice-based, randomized clinical trial of antihypertensive pharmacologic treatment and, in a specific subset, lipid-lowering, in 40,000 high-risk hypertensive patients including at least 55% African-Americans. The purpose of the antihypertensive trial is to determine whether the combined incidence of fatal coronary heart disease (CHD)) and non-fatal myocardial infarction differs between diuretic treatment and three alternative antihypertensive pharmacologic treatments: a calcium antagonist, an angiotensin converting enzyme (ACL) inhibitor, and an alpha adrenergic blocker. The purpose of the cholesterol-lowering component is to determine whether lowering serum cholesterol in moderately hypercholesterolemic men and women aged 60 years and older with a 3-hydroxymethylgiutaryl coenzyme A (HMG CoA) reductase inhibitor will reduce the combined incidence of fatal CHD and non-fatal myocardial infarction. Inclusion of the cholesterol- lowering component is contingent on obtaining an HMG-CoA reductase inhibitor, which has not been finalized at this time. Approval to proceed with the lipid-lowering trial will not be granted until the availability of this agent has been secured. Rather than using independently funded clinics, patients will be recruited through office-based practices and hypertension clinics which will be reimbursed by the Clinical Trials Center (CTC) on a per-patient basis. This contract is for the Clinical Trials Center. Some of the functions of the Clinical Trials Center include coordinating all data collection, storage of data, analysis activities related to the study, and recruiting and training (along with the NHLBI) appropriate clinical sites and core laboratories required to conduct the study.