CHEMISTRY SERVICES FOR NTP

本项目计划是对化学活动的补充支持。 毒物学承包商以及提供化学支持 化学致癌科的工作人员研究活动。这个 化学支持承包商的资源将用于：1)采购 在发出申请之前难以获得测试化学品 确保能够进行毒理学研究的建议；2)提供 散装化学品的特殊处理，如净化或颗粒 在剂量配方中使用之前可能需要的尺寸缩小；3) 确定可能对评估产生影响的低水平杂质 致癌研究结果；4)为某些测试提供信息 协助研究设计的化学物质，如建议剂量的稳定性 车辆或车辆所能达到的最大浓度； 5)评估和解决毒理学遇到的分析问题 承包商和6)为内部研究提供化学支持，包括 组织或生物体液中测试物品或代谢物的分析。

This project plan is for the supplemental support of chemistry activities of the toxicology contractors as well as to provide chemistry support for the staff research activities of the Chemical Carcinogenesis Branch. The resources of the chemistry support contractor will be used to: 1) procure difficult to obtain test chemicals prior to issuance of a Request For Proposals to ensure that a toxicology study can be conducted; 2) provide special handling of the bulk chemicals such as purification or particle size reduction that may be needed prior to use in dose formulations; 3) identify low level impurities that may have an impact on the evaluation of the carcinogenesis study results; 4) generate information for some test chemicals to assist in study design such as stability in the proposed dose vehicle or the maximum concentration in the vehicle that can be achieved; 5) evaluate and resolve analytical problems encountered by the toxicology contractors and 6) provide chemistry support for in-house studies including analysis of test article or metabolites in tissues or biological fluids.