5TH CONFERENCE--DRUG ABUSE, IMMUNOMODULATION AND AIDS

描述：(申请人摘要) 据报道，吸毒者对疾病的易感性 一个世纪。自从最初关于白细胞吞噬功能受损的报道以来 对于鸦片成瘾者，阿片剂和阿片剂的许多免疫调节模式 大麻类药物已经证明了这些药物有能力改变 各种动物的免疫系统，包括啮齿动物、猫、灵长类和 人类。神经元阿片剂和大麻受体的克隆开启了一种 研究这些药物在外周的作用的新途径 免疫系统。尽管这一明确的相关结果表明 阿片类药物通过G偶联受体调节免疫功能，而这 调制对动物受试者有显著的健康后果，它 一直不可能证明滥用药物和 使用流行病学方法研究艾滋病的进展情况。探索其中蕴含的含义 在这些成果中，提议在#年举行一次卫星会议。 结合将在田纳西州纳什维尔举行的1997年国家发改委会议。这个 建议的主题包括药物受体表达的基础研究。 外周细胞与细胞间相互作用的信号转导 各种神经免疫循环激素，如细胞因子，对 药物滥用与各种传染病的相互关系 动物。这次会议的目的是将两个基本的 研究人员和临床研究人员讨论他们的相关性 调查结果。一些新手科学家将被授予青年调查员 旅游奖励，以激发他们对药物滥用领域的兴趣 一般，特别是神经免疫学。最后，评选结果 会议将以一系列评论的形式发表在 神经免疫学或一本个人论文的书。希望这一天 会议将促进更好地理解两国之间的分歧 基本结果和动物模型研究与人类艾滋病研究相结合。

DESCRIPTION: (Applicant's Abstract) Susceptibility of drug addicts to disease has been reported anecdotally for a century. Since the initial reports of impaired phagocytosis by leukocytes from opium addicts, many models of immunomodulation by opiates and cannabinoids have demonstrated the ability of these drugs to alter the immune systems of a variety of animals including rodent, cat, primate and human. The cloning of neuronal opiate and marihuana receptors has opened a new avenue for investigating the role of these drugs in the peripheral immune system. Despite this clear pathway of linked results suggesting that opiates modulate immune function via G-coupled receptors, and that this modulation has significant health consequences for the animal subject, it has not been possible to demonstrate a relationship between drug abuse and AIDS progression using epidemiological methods. To explore the implication of these results, it is proposed that a satellite meeting be held in conjunction with the 1997 CPDD meeting to be held in Nashville, TN. The proposed topics range from basic studies on the expression of drug receptors on peripheral cells and signal transduction through interactions with various neuroimmune circulatory hormones, like the cytokines, to studies of the interrelationship between drug abuse and infectious disease in various animals. The aims of the meeting are to bring together both basic researchers and clinical investigators to discuss the relevance of their findings. A number of beginning scientists will be given Young Investigator travel awards to stimulate their interest in the area of drug abuse in general and neuroimmunology in particular. Finally, the results of the meeting will be published either as a series of reviews in the Journal of Neuroimmunology or a book of individual papers. It is hoped that the meeting will foster a better understanding of the dichotomy between the basic results and animal model studies with the human AIDS studies.