ADAPTATIONS TO HYPOXIA

这是一份重新提交的申请， 包括5个调查机制的分项目， 对缺氧的各种反应的影响。 其中三个继续 长期以来， 循环-血管收缩和肺循环的发展 缺氧引起的高血压。 拟议的研究探讨 缺氧对肺血管内皮细胞和平滑肌细胞的直接影响 肌肉，遗传决定因素和外膜的作用 成纤维细胞在缺氧性肺动脉高压的发展中的作用。 其他项目建议调查对下列问题的澄清反应： 遗传因素对缺氧的调节及缺氧的影响 对妊娠的全身血管反应。 有相当大 这些项目之间的相互干扰， 科学原则，共享专业知识和资源。 信息 从这些研究中得出的结果应该可以提供关于 缺氧对肺循环的影响，呼吸控制， 妊娠期的全身循环变化。

This is a resubmission seeking renewal of a 20-year program encompassing 5 sub-projects which investigate mechanisms and implications of various responses to hypoxia. Three of these continue a long standing line of investigation concerning the pulmonary circulation-the development of vasoconstriction and pulmonary hypertension in response to hypoxia. The proposed studies explore direct effects of hypoxia on pulmonary vascular endothelium and smooth muscle, genetic determinants, and the role of the adventitial fibroblasts in the development of hypoxic pulmonary hypertension. Other projects propose to investigate the ventilatory response to hypoxia and its modulation by genetic factors and the effect of hypoxia on systemic vascular response to pregnancy. There is considerable cross-talk amongst these projects with respect to common underlying scientific principles, shared expertise and resources. Information resulting from these studies should provide insights into the effects of hypoxia on the pulmonary circulation, ventilatory control, and systemic circulatory changes in pregnancy.