FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS

虽然使用强化母乳(FMM，母亲自己的乳加 补充蛋白质、矿物质和维生素)喂养早产儿 婴儿在增加，这对母亲来说是一个艰难的过程，可能 变得昂贵。然而，发病率较低，住院时间较短 成本变得不那么重要了。这项研究的主要假设是 FMM保护早产儿免受迟发性败血症和/或NEC的影响 与喂食婴儿相比，缩短了住院时间 早产儿配方奶粉，因为它提供了针对 新生儿环境中的常见病原体。次要假设[原文如此] 这将受到考验的是：1)健康状况的改善，但增长速度放缓 与配方奶喂养的早产儿相比，FMM喂养的早产儿继续超越 住院；以及2)产奶量不足与 母亲的压力可以通过常见的托儿所做法来减轻 母亲和婴儿之间的皮肤对皮肤的接触。 小于30周的早产儿(n=272)将完成一项研究 具体目标如下：1)确定败血症的发生率 和/或NEC和住院时间的随机试验 喂养早产儿的FMM添加或强化 巴氏杀菌供体母乳或早产配方奶粉和非随机 FMM与早产公式的比较；2)确定关系 在系列牛奶样本中的特定功能抗体效价之间 病原体特异性败血症的发生率(表皮葡萄球菌， 金黄色葡萄球菌)，并确定特定的苗圃方案， 例如母婴之间的皮肤接触会影响 血清和牛奶中功能性抗体的研制；30检测 FMM与FMM的长期后遗症(生长、身体成分、健康) 早产儿的配方奶喂养，以及4)确定 早产儿母亲应激与产奶量的关系 婴儿，以及4)确定皮肤影响之间的关系 皮肤收缩作为一种减轻压力的方法。

Although the use of fortified mother's milk (FMM, mother's own milk plus supplemental protein, minerals, and vitamins) for feeding premature infants is increasing, it is a difficult process for the mothers and may become costly. However, with less morbidity and shorter hospitalization cost becomes less relevant. The primary hypothesis of this study is that FMM protects the premature infant from late-onset sepsis and/or NEC and shortens the duration of hospitalization compared with the feeding of preterm formula because it provides specific functional antibody against common pathogens in the neonatal environment. Secondary hypothesis [sic] that will be tested are: 1) The improved health but slower growth tof the FMM fed compared with the formula-fed premature infant continues beyond hospitalization; and 2) Insufficient milk production is related to maternal stress which can be reduced by the common nursery practice of skin-to-skin contract between mother and infant. Premature infants less than 30 weeks (n = 272) will complete a study of the following specific aims: 1) To determine the incidence of sepsis and/or NEC and duration of hospitalization in both a randomized trial of feeding premature infants FMM supplemented either with fortified pasteurized donor human milk or preterm formula and in a non-randomized comparison of FMM and preterm formula; 2) To determine the relationship between specific functional antibody titers in serial milk samples the incidence of pathogen--specific sepsis (Staphylococcus epidermidis, Staphylococcus aureus), and to determine if specific nursery protocols, such as skin-to--skin contact between mother and infant affect the development of functional antibody in serum and milk; 30 To determine long-term sequelae (growth, body composition, health) of FMM versus formula feeding in premature infants, and 4) To determine the relationship between stress and milk production in mothers of premature infants, and 4) To determine the relationship between the effect of skin- to-skin contract as a stress reduction method.