PHOTOACOUSTIC ULTRASONOGRAPHY

我们建议图像的吸收特性的区域变化， 生物组织在近红外和微波区的 使用光声超声（PAUS）成像的电磁频谱 我们实验室最近开发的原理。迄今为止的研究 证明应该可以对低对比度结构进行成像 在一个5.6厘米的压缩乳房使用安全水平的红外辐射 （λ = 1.064微摩尔）。我们将把红外线的工作扩展到 我们可以在体外对切除的乳房组织进行成像。我们还计划 将我们的研究扩展到433 MHz微波辐射， 预期对比度和组织穿透性明显更好 比在红外线。 在为期三年的研究期间，我们将： I.模拟PAUS成像光能沉积的能力 在1.064微摩尔的人类乳房内的模式，基于一组 在圆柱体表面上进行的光声测量。 二.开发和测试PAUS仪器，以执行初步 433 MHz的实验。 三.开发和测试PAUS仪器，用于对人体组织成像， 1.064微摩尔。 四.开发和测试解调平滑变化的算法， 在1.064处获得的PAUS图像的深度相关激发能量 微摩尔。 诉开发和测试PAUS仪器，用于对人体组织成像， 在433 MHz下。 六.使用PAUS仪器量化图像对比度和对比度 在1.064微摩尔下， 433 MHz

We propose to image regional variations in the absorption properties of biologic tissue in the near infrared and microwave regions of the electromagnetic spectrum using photoacoustic ultrasound (PAUS) imaging principles developed recently in our laboratory. Research to date has demonstrated that it should be possible to image low contrast structures in a 5.6 cm compressed breast using safe levels of infrared radiation (lambda = 1.064 micromoles). We will extend our work in the infrared to a point where we can image excised breast tissue in vitro. We also plan to extend our investigations to 433 MHz microwave radiation where image contrast and tissue penetration are expected to be significantly better than in the infrared. During the three-year research period we will: i. Simulate the ability of PAUS to image optical energy deposition patterns within the human breast at 1.064 micromoles, based on a set of photoacoustic measurements made over the surface of a cylinder. ii. Develop and test PAUS instrumentation to perform preliminary experiments at 433 MHz. iii. Develop and test PAUS instrumentation for imaging human tissues in vitro at 1.064 micromoles. iv. Develop and test algorithms for demodulating the smoothly varying, depth-dependent excitation energy from PAUS images obtained at 1.064 micromoles. v. Develop and test PAUS instrumentation for imaging human tissues in vitro at 433 MHz. vi. Use PAUS instrumentation to quantify image contrast and contrast patterns of excised, human breast tissue in vitro at both 1.064 micromoles and 433 MHz.