DETECTION OF PRESYMPTOMATIC ALZHEIMER DISEASE BY FMRI

本申请提出要研究功能磁共振、结构磁共振、 和神经心理功能不同水平的个体 患阿尔茨海默氏症的风险。风险组将由以下人员定义 家族史和载脂蛋白-E等位基因状态。少校 假说是大脑皮层激活的模式和程度 视觉对抗命名任务将有很大的不同 AD高危和低危受试者。调查人员还将 确定结构/解剖上的差异是否存在于 以及这些MRI表现是否与 神经心理功能。这个应用程序解决了一个非常 AD研究的重要领域。初步的fMRI数据将是 如果包括老年受试者或有阿尔茨海默病风险的受试者，则更强。这个 使用两种不同的策略来确定中等风险组 可能会造成一些困难和解释。初步分析 FMRI数据是组平均数据，而不是发布日期：4/04/1997。

This application proposes to study functional MRI, structural MRI, and neuropsychological function in individuals at different levels of risk for Alzheimer's Disease. The risk groups will be defined by family history and by apolipoprotein-E allele status. The major hypothesis is that the pattern and extent of cortical activation during a visual confrontation naming task will differ substantially between subjects at high and low risk for AD. The investigators will also determine whether structural/anatomic differences exist between the groups and whether these MRI findings correlate with neuropsychological function. This application addresses a very important area in AD research. The preliminary fMRI data would be stronger if it included elderly subjects or these at risk for AD. The use of two different strategies for identifying intermediate risk groups may pose some difficulties and interpretation. The primary analyses of fMRI data is group mean data rather date released: 04/04/1997.