NEURONAL PATHWAYS OF THE BASAL GANGLIA

描述：这项研究的最终目标是为 了解基底节在运动控制中的作用。这个 对基底神经节回路的准确了解对 基底节研究的理论和实践应用 精神错乱。这项建议的目的是实现以下两个目标 明确的目标。第一个具体目标是证实我的假设 皮质信号被传递到基底节的输出核， 延髓内侧核和黑质网状部 不同的核，新纹状体和丘脑底核。这个 研究人员将检查对感觉运动皮质的刺激 在基底节输出核诱导双突触兴奋，这是 通过丘脑底核和双突触抑制 是通过新纹状体调节的。第二个具体目标是测试我的 假设苍白球是基底神经系统的控制中心。 苍白球汇聚来自新纹状体的输入的神经节 而丘脑底核和苍白球的输出为对照 整个基底节的活动。调查人员的研究，如 和其他物种一样，已经证明了苍白球 整合来自新纹状体和丘脑底核的信息。这个 苍白球也大量投射到新纹状体和基底部。 输出神经节、丘脑内侧核和黑质 网状部。调查人员的研究将重点放在 苍白球投射到新纹状体和内侧丘脑核。 这项研究将表征生理特性和 苍白球投射到新纹状体和内侧丘脑核。在… 在拟议的项目结束后，他们将能够提供一个解剖 以及解释GP神经元活动的生理学基础 影响其他基底节核团。拟议研究的方法 包括：单元记录、细胞内记录和染色 麻醉动物和脑片制备。

DESCRIPTION: The ultimate goal of the study is to contribute to the understanding of the function of the basal ganglia in movement control. The precise knowledge of the circuitry of the basal ganglia is important for both theoretical and practical application to the study of basal ganglia disorders. The purpose of this proposal is to achieve the following two specific aims. The first specific aim is to substantiate my hypothesis that cortical signals are transmitted to the basal ganglia output nuclei, the entopeduncular nucleus and the substantia nigra pars reticulata, through two different nuclei, the neostriatum and the subthalamic nucleus. The investigators will examine whether stimulation of the sensorimotor cortex induces, in basal ganglia output nuclei, a disynaptic excitation which is mediated through the subthalamic nucleus, and a disynaptic inhibition which is mediated through the neostriatum. The second specific aim is to test my hypothesis that the globus pallidus is the control center of the basal ganglia in that the globus pallidus converges inputs from the neostriatum and the subthalamic nucleus and the output of the globus pallidus controls the activity of the entire basal ganglia. The investigator's studies, as well as those of others, have demonstrated that the globus pallidus integrates inputs from the neostriatum and the subthalamic nucleus. The globus pallidus also projects heavily to the neostriatum and the basal ganglia output nuclei, the entopeduncular nucleus and the substantia nigra pars reticulata. The investigators study will focus on the effects of pallidal projections to the neostriatum and the entopeduncular nucleus. This study will characterize physiological properties and the role of pallidal projections to the neostriatum and the entopeduncular nucleus. At the end of the proposed projects, they will be able to offer an anatomical and physiological basis for explaining how the activity of GP neurons influence other basal ganglia nuclei. The methods for the proposed study include: unit recording, intracellular recording and staining in both anesthetized animals and brain slice preparations.