METHAMPHETAMINE ABUSE PHARMACOTHERAPY IN AIDS PATIENTS

描述：（申请人摘要） 与性活动相关的甲基苯丙胺滥用现已流行 在同性恋和双性恋男性中。 我们提出了一个调查的有效性，两个有前途的推定 兴奋剂滥用药物治疗，地昔帕明和舍曲林，作为禁欲 样品中甲基苯丙胺（MAMPH）依赖性的促进治疗 有艾滋病症状的同性恋和双性恋男性。 的 药物治疗将作为与药物治疗相关的连续治疗应用。 艾滋病医疗诊所。 本研究将采用安慰剂对照、双盲、随机 分配，三单元平行组设计，将评估120名受试者 在12周的实验治疗期间，在1、3和6时进行随访 个月 我们假设服用地昔帕明或舍曲林的患者， 而不是安慰剂，将证明： 1. MAMPH滥用严重程度降低，可操作为MAMPH降低 用于尿液中的定量GCMS以及自我报告的量和频率 随着对MAMPH渴望的控制增加， 戒断和保留药物治疗。 2. 更多地利用艾滋病医疗服务， 参与出勤率和遵守 规定的艾滋病医疗领域。 3. * 减少高风险性行为和吸毒的频率， 与性活动有关， 自我报告的不安全性行为和同时使用药物的性 行为评估。

DESCRIPTION: (Applicant's Abstract) Methamphetarnine abuse in conjunction with sexual activity is now epidemic among homosexual and bisexual males. We propose an investigation of the efficacy of two promising putative stimulant abuse pharmacotherapies, desipramine and sertraline, as abstinence facilitation treatments for metharnphetamine (MAMPH) dependence in a sample of homosexual and bisexual males with symptomatic AIDS. The pharmacotherapies will be applied as adjunctive treatment linked to a medical care clinic for AIDS. The investigation will employ a placebo controlled, double-blind, random assignment, three cell parallel group design that will assess 120 subjects during 12 week's of experimental treatment, with follow-up at 1, 3 and 6 months. We hypothesize that subjects on active desipramine or sertraline, but not placebo, will evidence: 1. Decreased MAMPH abuse severity, operationalized as a decrease in MAMPH use on quantitative GCMS in urine and on self-reported amounts and frequency of use, as increased control over MAMPH craving and as increased durations of abstinence and retention in drug treatment. 2. Increased utilization of medical services for AIDS, operationalized as increases on measures of engagement attendance, and compliance with prescribed domains of AIDS medical care. 3. Decreased frequency of high risk sexual behaviors and of drug use in conjunction with sexual activity operationalized as decreases in self-reports of unsafe sexual behaviors and concurrent drug use on sexual behavior assessments.