ANTIVIRAL/BIOACTIVE COMPOUNDS--SYNTHESIS AND CHEMISTRY

本研究的总体目标是对基本方面的研究 合成有机化学和生物有机化学及其应用 将生物化学和医学的重要问题转化为学科。特定的 研究项目包括：(1)治疗药物的合成 抗人类免疫缺陷病毒药物；(2)合成 用于器官移植的免疫抑制剂；(3)抗生素的合成， 米非司酮A；(4)激素物质米非司酮的合成； 环磷酸腺苷合成酶激活剂Forskolin的合成；(6)合成 抗炎药伪蝶呤E的合成；(7) 蛋白质转运和加工的抑制剂，布雷菲尔丁A；(8) 起始因子4D生物合成抑制剂的合成(9) 新型5-羟色胺摄取抑制剂的合成。生物有机学研究是 前列腺素和血栓素与其结合的研究进展 受体，二十烷类化合物作用的12-脂氧合酶途径，以及 胆固醇的生物合成。最后，我们需要新的方法论 将研究有机合成，特别是有机合成的方法 对映体选择性和催化合成。

The overall objective of this research is the study of fundamental aspects of synthetic organic and bioorganic chemistry and the application of these disciplines to important problems of biochemistry and medicine. Specific projects for study include the following: (1) synthesis of therapeutic agents against human immunodeficiency virus; (2) synthesis of immunosuppressants for organ transplants; (3) synthesis of the antibiotic, crinipellin A; (4) synthesis of the hormonal substance, miroestrol; (5) synthesis of the activator of cyclic AMP synthase, forskolin; (6) synthesis of the antiinflammatory agent, pseudopterosin E; (7) synthesis of the inhibitor of protein translocation and processing, brefeldin A; (8) synthesis of the inhibitors of biosynthesis of initiation factor 4D; (9) synthesis of new serotonin uptake inhibitors. Bioorganic studies are proposed on the binding of prostaglandins and thromboxanes to their receptors, the 12-lipoxygenase pathway of eicosanoid action, and cholesterol biosynthesis. Finally, new methodology which is needed in organic synthesis will be investigated, especially methods for enantioselective and catalytic synthesis.