OPIOIDS AND ORGAN PRESERVATION

这个项目研究了人体的生理效应和潜在的 Delta阿片肽和a的作用生化机制 器官相关蛋白因子HIT(冬眠诱导触发) 保存和保护。在一项肺移植实验中， 经24小时保存后，肺功能正常 当移植到宿主动物体内时。在另一项实验中，三角洲 检测阿片肽DADLE对心肌的潜在保护作用 用离体兔的心脏做动作。在将心脏置于 缺血时，心脏在一段时间内接受一次DADLE灌流 15分钟。DADLE预灌流的这一过程戏剧性地 18小时全球训练后心肌功能恢复的改善 与对照组相比，4EC时出现缺血。我们目前正在检查 DADLE在某些类型的中枢神经系统损伤中的潜在用途。

This project examines the physiological effects and the underlying biochemical mechanisms of the action of the delta opioid peptides and a related protein factor HIT (Hibernation Induction Trigger) in organ preservation and protection. In a lung transplantation experiment, the lung, after 24 hours of preservation with the HIT, functioned normally when transplanted into the host animal. In another experiment, the delta opioid peptide DADLE was examined for potential myocardial protective action using isolated rabbit hearts. Before subjecting the heart to ischemia, the hearts received a single perfusion of DADLE over a period of 15 minutes. This procedure of DADLE preperfusion dramatically improved recovery of myocardial functions following 18 hours of global ischemia at 4EC when compared to controls. We are currently examining the potential use of DADLE in certain types of CNS damage.