POSTMENOPAUSAL HORMONE REPLACEMENT AND CARDIOVASCULAR HEMODYNAMICS/BLOOD VOLUME

本研究的目的是确定绝经后妇女 激素替代治疗对心脏功能和血浆容量的影响， 为了确定这种作用是否与血清肾素的变化有关， 血管紧张素II和醛固酮。 本研究特别提出， 确定醋酸甲羟孕酮，17 β-雌二醇， 和17 B-雌二醇/醋酸甲羟孕酮对心输出量、卒中 容积、射血分数、左室壁厚度和血浆 在特定时间点之前和在特定时间点时全身人体模型中的体积 激素替代疗法 心脏参数将 多普勒超声心动图测定血浆容量，125 I-白蛋白测定血浆容量 稀释和免疫测定的激素。 从1996年7月1日至1996年11月30日，18名患者中有12名被招募参加四项研究。 月研究。 初步数据显示心输出量增加20-25% 和每搏输出量的变化。 经过四 个月，收缩末期容积下降约20%，射血 分数增加约10%，左心室质量增加约10%。 约8%与17 B-雌二醇或联合17 B-雌二醇/ 醋酸甲羟孕酮 在研究的最后6个月，我们预计招募将 将提供完整的血容量数据。

The goal of this study is to determine the effect of postmenopausal hormone replacement therapy on cardiac function and plasma volumes and to determine if this effect is related to changes in serum renin, angiotensin II and aldosterone. This study proposes specifically to determine the effects of medroxyprogesterone acetate, 17 B-estradiol, and 17B-estradiol/medroxyprogesterone acetate on cardiac output, stroke volume, ejection fraction, left ventricular wall thickness and plasma volume in a whole body human model before and at certain time points on sequential hormone replacement therapy. Cardiac parameters will be determined by Doppler echocardiography, plasma volume by 125I-albumin dilution, and hormones by immunoassay. From 7/1/96-11/30/96, 12 of 18 patients were recruited for the four month study. Preliminary data show a 20-25% increase in cardiac output and stroke volume with estrogen plus progestin in one month. After four months, end systolic volume declines by approximately 20%, ejection fraction increases by about 10% and left ventricular mass increases by about 8% with 17B-estradiol or combined 17B-estradiol/ medroxyprogesterone acetate. In the last 6 months of the study, we anticipate recruitment will be complete and blood volume data will be available.