ADVERSE EFFECTS OF OXIDATIVE STRESS DURING PREGNANCY

氧化损伤与以下几种疾病的病理有关 疾病，但直到最近才有人建议在 不利的生殖条件。许多环境和职业 暴露是已知的促氧化剂(例如，许多溶剂和金属)，以及 它们可能会导致氧化损伤，从而对生殖产生不利影响。这 一项研究项目探索了环境与环境之间的关系 暴露、氧化应激和不利的生殖条件。 我们的工作有两个主要目标。首先是对Small的持续分析 关于金属和其他工业产品水平的现有数据样本 污染物、氧化损伤的标志物和生殖结果 孕妇和母婴配对居住在 保加利亚各地区的工业企业。今年我们有 完成了化工厂污染区域的数据分析 排放。保加利亚工作的第二个目标是进行试点 将解决抗-HBs标记物的变异量的研究 氧化剂和氧化剂状态由季节性和个体内变化引起 以及存储程序。20名非怀孕妇女服用了系列药物 血液样本；结果表明，样本不能储存 完全不会超过几个小时，而不会改变 谷胱甘肽和过氧化脂质含量显著升高。内部级别- 个体差异性正在被确立。另外，20名孕妇将 日期已在预订时登记，并正在观察是否有变化 随着怀孕的进展，生物标记物。试点中的次要活动 研究是分析孕妇的饮食数据，以确定 氧化状态标志物与抗氧化剂膳食摄入量的关系 氧化剂。

Oxidative damage has been implicated in the pathology of several diseases, but only recently has it been suggested to have a role in adverse reproductive conditions. Many environmental and occupational exposures are known pro-oxidants (e.g., many solvents and metals), and they may adversely affect reproduction by causing oxidative damage. This research project explores the relationship between environmental exposures, oxidative stress, and adverse reproductive conditions. We working with two major aims. First is the continued analysis of small samples of existing data concerning levels of metals and other industrial pollutants, markers of oxidative damage, and reproductive outcome in pregnant women and maternal-infant pairs living in the vicinity of industrial enterprises in various areas of Bulgaria. This year we have completed analysis of data from an area polluted by chemical plant emissions. The second aim of the Bulgarian work is to conduct a pilot study that will resolve the amount of variability in the markers of anti- oxidant and oxidant status due to seasonal and intra-individual variation and to storage procedures. Twenty non-pregnant women have given serial blood samples; the results indicated that the samples could not be stored at all for more than a few hours without altering the level of glutathione and lipid peroxides significantly. The level of intra- individual variability is being established. Also, 20 pregnant women to date have been enrolled at booking and are being observed for changes in biomarkers as pregnancy progresses. A secondary activity in the pilot study is to analyze dietary data from pregnant women to determine the relationship of oxidative status markers and dietary intake of anti- oxidants.