HOLMIUM LASER FOR REVERSAL OF CEREBRAL ARTERY VASOSPASM

脑血管痉挛是一种引发生命危险的疾病 通过出血的动脉瘤导致严重的神经损伤。 患有脑血管痉挛的患者数量在 超过20,000，并且这种情况通常会永久性地产生 30-40岁年龄组的致残性影响或死亡 表现出最高的发病率。这种情况对 药物，很难用球囊血管成形术治疗。论阶段 我，我们开发了一种脉冲Ho激光驱动的导管， 释放出的流体波可靠而永久地缓解 失血致犬脑动脉痉挛。在阶段11期间， 我们将首先验证要用于的确切过程和硬件 患者，然后进行该方法的第一次临床试验 罂粟碱耐药脑动脉血管痉挛患者。一个 血管痉挛的救命治疗将直接由此产生 工作。 目前，建议的商业应用还没有永久性的 严重脑动脉血管痉挛的治疗。大致 10,000名健康的年轻人遭受永久性脑损伤，因为 脑血管痉挛每年都会发展成永久性的 基于激光的治疗将显著减少 因这种情况而致残的患者。

Cerebral artery vasospasm is a life-threatening condition triggered by bleeding aneurysms that can cause severe neurological damage. The number of patients suffering from cerebral vasospasm is in excess of 20,000, and the condition often produces permanently crippling effects or death in the 30-40 year old age group that exhibits the highest incidence. The condition responds poorly to drugs and is difficult to treat with balloon angioplasty. On Phase I, we developed a pulsed-holmium-laser-driven catheter which emitted fluid waves that reliably and permanently relieved hemorrhage-induced spasm in canine brain arteries. During Phase ll, we will first verify the exact procedure and hardware to be used in patients, then conduct the first clinical trial of this approach in patients with papaverine-resistant cerebral artery vasospasm. A life-saving treatment for vasospasm will result directly from this work. PROPOSED COMMERCIAL APPLICATIONS At present, there is no permanent treatment for severe cerebral artery vasospasm. Approximately 10,000 healthy, young adults suffer permanent brain damage due to cerebral vasospasm each year, and the development of a permanent laser-based treatment would significantly reduce the number of patients disabled by this condition.