MINATURE RADFETS--RADIOIMMUNO/BRACHYTHERAPY

该项目将满足对实时、连续测量的需求 体内的辐射剂量。在第一阶段下，发展一套 微电子制造技术在微电子制造中的应用 辐射敏感场效应晶体管(RADFET)和普通 在单片硅衬底上成功地制作了晶体管器件 演示了。智能辐射传感器和线性微型探头 传感器阵列将在第二阶段进行设计和制造。 用于检测、信号处理的微电子电路。A/D转换， 并将设计、制造和评估计算机接口。 用于探头控制、数据采集和实时数据显示的软件 将会被开发出来。这些组件系统将组装成一个 将进行评估的多站点数字输出辐射剂量测量探头 在第三阶段研究之前模拟活体测量的模体中 在诊所里。微型传感器的二维布置将 允许剂量成像。 据报道，每年约有100万新的癌症病例。 仅在美国；其中近600.000的病例接受了放射治疗。 放射免疫分析疗法(RIT)目前正在研究中，并在 临床试验作为一种新的肿瘤靶向技术。立体定向 伴随着大剂量梯度的放射治疗正在发展。这个 仪器将允许实时剂量率和总累积剂量 RIT和立体定向放射治疗期间的测量。这 目前的技术无法获得的信息，将带来更好的结果 治疗前计划和治疗后评估以及潜力 放射免疫治疗中放射暴露的最佳化。 建议的商业应用：这一开发将导致第一个 辐射传感器阵列，提供实时剂量率和 体内应用的总剂量。虽然最初的动机是强大的 对量化潜在或放射免疫治疗的兴趣，传感器 也应该在近距离放射治疗、立体定向治疗中得到广泛应用 放射治疗。在研究环境中使用，并作为临时病人使用 监视器。剂量图像来自放置在 病人有很大的潜力。

This project will address the need for real-time, continuous measurement of radiation dose in vivo. Under Phase I, the feasibility of developing a microelectronic fabrication process for simultaneous manufacture of radiation sensing field effect transistors (RADFETs) and ordinary transistor devices on a single silicon substrate was successfully demonstrated. Smart radiation sensors and miniature probes with linear arrays of sensors will be designed and manufactured under Phase II. Microelectronic circuits for detection, signal processing. A/D conversion, and computer interfacing will be designed, manufactured, and evaluated. Software for probe control, data acquisition, and real-time data display will be developed. These component systems will be assembled into a multisite, digital output radiation dosimetry probe that will be evaluated in phantoms emulating in vivo measurements in advance of Phase III studies in the clinic. Two-dimensional arrangements of the miniature sensors will permit dose imaging. Each year approximately 1 million new cases of cancer are reported in the US alone; nearly 600.000 of those cases are treated with radiation. Radioimmunoassay therapy (RIT) is currently under investigation and in clinical trials as a novel technique of targeting tumors. Stereotactic radiotherapy with attendant large dose gradients is growing. The instrument will allow real time dose rate and total accumulated dose measurements during RIT and stereotactic radiotherapy treatment. This information, unobtainable by current techniques, will result in better pre-treatment planning and post-treatment evaluation as well as potential optimization of radiation exposure during radioimmunotherapy. PROPOSED COMMERCIAL APPLICATION: This development will lead to the first array of radiation sensors which provide both real-time dose rate and total dose for in vivo applications. While initially motivated by strong interest in quantifying the potential or radioimmunotherapy, the sensors should also find wide application in brachytherapy, stereotactic radiotherapy. in investigational settings and use as an on-patient monitor. Dose images derived from 2-D arrays of sensors placed on the patient has significant potential.