IMMUNE DISREGULATION IN MALARIA AND CONCOMMITANT MEASLES

描述 初步研究：年村庄疟疾寄生虫率为57% 儿童占41%，成人占41%。记录在案的病例增加了30% 在1995至1996年间。1995年5月爆发了29%的麻疹 死亡率。死亡率通常与继发性细菌有关。 感染，因此怀疑是免疫抑制。Quakyi博士建议 疟疾引起的TH1应答和TH2应答 麻疹可能会导致无能。用酶联免疫吸附试验检测疟疾AMA抗体相似 然而，在麻疹和非麻疹组中，较低的麻疹抗体 在疟疾寄生虫血症患者中观察到的，而不是 寄生虫阴性。 这些发现对地方病的流行具有重要的公共卫生指标。 如果在以下时间接种地区麻疹疫苗，效果可能会较差 因此，在寄生虫血症的高峰期，他们应该给予最低的 疟疾季节到了。 在雅温得医院接种麻疹疫苗的儿童将被邀请 定期抽血，以确定 麻疹和疟疾抗体的水平和持续时间， 通过细胞因子和同型分析对TH1/TH2反应进行分类，以及 外周血单核细胞对麻疹和疟疾抗原的增殖反应这 工作将有望产生足够的数据，形成RO1的基础 申请。

DESCRIPTION Preliminary studies: Malarial parasite rates in villages were 57% in children and 41% in adults. A 30% increase in recorded cases was seen between 1995 and 1996. In May 1995 there was a measles outbreak with 29% mortality. Mortality was often associated with secondary bacterial infections, thus immunosuppression was suspected. Dr. Quakyi proposed that the TH1 responses elicited by malaria and the TH2 responses elicited by measles may result in anergy. Malarial AMA antibodies were similar by ELISA in both measles and non-measles groups, however, lower measles antibodies were observed for people with malaria parasitemia, than people who were parasite negative. These findings have an important public health indication for the endemic area Measles vaccinations will probably be less effective if given during the high parasitemia season, therefore, they should be given at the low malaria season. Children being vaccinated for measles at Yaounde hospital will be invited to return and have their blood drawn at regular intervals in order to determine the levels and duration of measles and malarial antibodies, the categorization of TH1/TH2 responses via cytokine and isotyping assays, and the proliferative responses of PBMC to measles and malarial antigens. This work will hopefully lead to enough data form the basis for a RO1 application.