OCULOMOTOR RANGE IN HEALTH AND DISEASE

凝视的快速转移可以通过眼睛的移动来实现 单独(眼跳)或眼睛和头部的联合运动(眼球-头部) 扫视)。通常动眼范围(COMR)是大约 受试者容易凝视的“中心”轨道位置 通过眼球扫视来改变。先前的研究表明，COMR可能是 大约正负15度，但从来没有人研究过 系统地。COMR之所以重要，是因为：1)其原因 是否存在尚不清楚；它可能反映了大脑能力的局限性 为了补偿动眼植物，因此绘制COMR图将 也绘制出这些限制；2)COMR反映了大脑在 完成给定任务的两种不同方法(即使用眼睛- 仅限或眼球扫视)。这种二元选择过程是 可使用电生理技术，但行为学研究 COMR是一个必要的先决条件。拟议的调查将 确定测量COMR的方法，描述眼睛的运动学 COMR内部和外部的运动决定COMR是否是塑料的， 并观察脑、眶、颈疾病对COMR的影响。 这些研究还将阐明这种疾病过程对 视觉功能。此外，通过量化眼球运动， 偏心轨道位置，这些研究将确立有效性 以及一些常见的眼球运动临床测试的局限性。

Rapid shifts of gaze can be accomplished either by movement of the eyes alone (eye saccades) or combined movements of eyes and head (eye-head saccades). The customary oculomotor range (COMR) is that region about "central" orbital position within which a subject tends to make gaze changes by eye saccades. Prior studies suggest that COMR may be approximately plus or minus 15 degrees but it has never been studied systematically. COMR is important because: 1) The reason for its existence is unclear; it may reflect limitations in the brain's ability to compensate for the oculomotor plant, and therefore mapping COMR would also map these limitations; 2) COMR reflects the brain's choice between two different methods of accomplishing a given task (i.e., to use an eye- only or an eye-head saccade). This sort of binary selection process is accessible to electrophysiologic techniques but behavioral studies of COMR are a necessary prerequisite. The proposed investigations would determine methods of measuring COMR, describe the kinematics of eye movements made within and beyond COMR, determine whether COMR is plastic, and examine the effects of diseases of brain, orbit, and neck on COMR. These studies will also clarify the effects of such disease processes on visual function. Furthermore, by quantifying eye movements about eccentric orbital positions, these studies will establish the validity and limitations of some common clinical tests of eye movements.