FUNCTIONAL NEUROIMAGING OF SENSORY-MOTOR INTEGRATION

这项提议的目标是：i)优化和验证正电子 发射断层扫描(PET)激活技术作为一种功能检测方法 单个受试者的脑图，以及2)将这些技术应用于 更好地理解人类感觉-运动整合的过程。 PET研究将使用放射性标记水作为测量手段 血液流动的区域性变化对行为任务的反应。这个 这项提案的方法论方面将侧重于改进 通过使用更好的成像协议的信噪比，开发 用于分析个人数据的更准确的统计模型 受试者，并通过比较 结果与使用其他功能评估方法获得的结果相一致。 这些方法论调查的目标是开发 脑功能成像是研究正常人的有效、严谨的工具 以及个别受试者的脑生理异常。 该提案的神经科学部分的目标是使用 这一工具可以更好地了解人类的感觉-运动整合。 初步研究将绘制正常受试者的感觉-运动过程图 感觉输入通道和运动输出通道的功能。 顶叶参与感觉-运动任务将是 特别感兴趣，但一个或多个广泛的 参与感觉-运动整合的大脑皮层网络是预期的。 进一步的研究将检查感觉-运动的偏侧化。 正常受试者寻找大脑半球证据的过程 不对称性。在该提案的最后两年，患有 感觉-运动障碍和/或脑结构正常损害 参与感觉-运动整合的研究将被研究。多式联运 临床观察、功能成像研究、解剖学的整合 影像研究和电生理测量将用于 进一步厘清正常受试者与患者的关系 大脑结构和功能之间的关系。

The objectives of this proposal are: i) to optimize and validate positron emission tomography (PET) activation techniques as a method of functional brain mapping in single subjects, and 2) to apply these techniques to better understand processes of sensory-motor integration in the human. PET studies will use radioactively labeled water as a means of measuring regional changes in blood flow in response to behavioral tasks. The methodologic aspects of this proposal will focus on improvements in signal-to-noise ratios by using better imaging protocols, development of more accurate statistical models for analyzing data from individual subjects, and independent validation of PET findings by comparing the results with those obtained using other methods of functional evaluation. The objective of these methodologic investigations is to develop functional brain imaging as a valid, rigorous tool for the study of normal and abnormal brain physiology in individual subjects. The objective of the neuroscientific component of the proposal is to use this tool to better understand sensory-motor integration in the human. Initial studies will map sensory-motor processes in normal subjects as a function of the sensory input modality and the motor output modality. Participation of the parietal lobe in sensory-motor tasks will be of particular interest, but the demonstration of one or more widespread cortical networks involved in sensory-motor integration is anticipated. Further studies will examine the -lateralization of sensory-motor processing in normal subjects to look for evidence of hemispheric asymmetries. During the final two years of the proposal, patients with sensory-motor deficits and/or with lesions in brain structures normally involved in sensory-motor integration will be studied. Multimodal integration of clinical observations, functional imaging studies, anatomic imaging studies, and electrophysiologic measurements will be utilized in normal subjects and in patients to further clarify the relationship between brain structure and function.