RADARS--A RAPID DATA ARCHIVAL AND RETRIEVAL SYSTEM

在人类基因组计划之后， 理解和治疗人类疾病是所有 在基因组中编码的成熟基因产物，即蛋白质组。 例如，了解正常和转换之间的差异 细胞中存在哪些蛋白质，以及它们是如何在 解释性修改是理解的重要信息 癌质谱是一种强有力的实验工具，用于高- 蛋白质的通量鉴定和表征， 快速获得大量有价值的实验数据的手段。 然而，分析这些数据可能非常耗时， 目前还没有一个集成的系统， 存储和快速检索蛋白质质谱和蛋白质序列。 我们建议开发一个快速数据存档和检索系统（RADARS） 用于蛋白质质谱实验的存储;该系统将 与一套用于自动化分析的工具集成， 蛋白质质谱和蛋白质与DNA序列的比较。雷达 将允许存储原始质谱， 实验条件和分析结果。 拟议的商业应用： 目前，许多制药和生物技术公司正在扩大 他们在大规模蛋白质分析中的努力， 新的药物靶点雷达将使分析和管理的 这些项目中产生的数据。

In the wake of the human genome project, the next important step towards understanding and curing human disease is the characterization of all mature gene products that are encoded in the genome, i.e. the proteome. For example, knowledge of the difference between normal and transformed cells in terms of which proteins are present and how they are post- translationally modified is important information for understanding cancer. Mass spectrometry is a powerful experimental tool for high- throughput identification and characterization of proteins and provides means for rapidly obtaining large amounts of valuable experimental data. However, the analysis of this data can be very time-consuming, and presently no integrated system exists for facile analysis, reliable storage and fast retrieval of protein mass spectra and protein sequences. We propose to develop a Rapid Data Archival and Retrieval System (RADARS) for the storage of protein mass spectrometry experiments; the system will be integrated with a suite of tools for the automated analysis and comparison of protein mass spectra and protein and DNA sequences. RADARS will allow for storage of the original mass spectra, description of the experimental conditions, and the results of the analysis performed. PROPOSED COMMERCIAL APPLICATIONS: Presently many pharmaceutical and biotechnology companies are expanding their efforts in large-scale protein analysis for the identification of novel drug targets. RADARS will enable the analysis and management of the data produced in those projects.