TISSUE PERFUSION AND BLOOD FLOW MONITORING TECHNOLOGY

毛细血管血流的评估对于许多医学领域具有重要意义。 程序和条件。激光多普勒两种光学相干技术 测速技术和动态激光散斑技术已被应用于血液测量。 流速。激光散斑对比度分析方法 先进的数字摄影优势延伸了传统的 激光散斑法是一种非扫描、全场的技术。这一阶段 我的目标是开发一种激光散斑幅度映射技术，用于 监测毛细血管血流速度，并证明 该技术达到或优于激光多普勒测速技术。 该项目的目标是开发一种低成本的定量设备 监测组织灌注量。第一阶段侧重于可行性 演示如何提供有关皮肤血流量的定量数据 动物模型。将在第二阶段开发一个原型，用于 临床研究。所提出的技术的优点是更快， 覆盖范围更广，更简单，非接触，更好的重复性。 建议的商业应用： 该光学装置将提供对组织的简单且非接触的监测 患者在整形和重建期间和术后的生存能力 外科手术包括皮瓣和手指再植，以及在创伤过程中 治疗程序。商业应用包括诊断 烧伤患者的情况，糖尿病患者的四肢，以及 适用于血管密度增加的患者，如皮肤癌。

The assessment of capillary blood flow is important for many medical procedures and conditions. Two optical coherent techniques, laser Doppler velocimetry and dynamic laser speckle, have been applied to measure blood flow velocities. The Laser Speckle Contrast Analysis method takes advantage of the advanced digital photography to extend the conventional laser speckle method to a nonscanning, full-field technique. The Phase I aim is to develop a laser speckle amplitude mapping technology for monitoring capillary blood flow velocity and demonstrate the accuracy of the technology at or better than that of the laser Doppler velocimetry. The goal of the project is to develop a low-cost device for quantitative monitoring of tissue perfusion. Phase I focuses on the feasibility demonstration to provide quantitative data on skin blood flow using animal models. A prototype will be developed in Phase II to use in a clinical study. The advantages of the proposed technique are faster, wider area coverage, simpler, noncontact, and better reproducibility. PROPOSED COMMERCIAL APPLICATIONS: The optical device will provide easy and noncontact monitoring of tissue viability for patients during and after plastic and reconstructive surgery involving flaps and digit reattachment, and during trauma treatment procedures. Commercial application includes diagnosing the conditions of burn patients, the extremities of diabetic patients, and for patients with increased vascular density such as skin cancer.