Dynamic regulation of cell signalling scaffolds

该项目旨在确定细胞如何利用支架类型的信号蛋白，随着时间的推移协调对正常发育和生理至关重要的各种细胞反应。该项目期望产生具有广泛相关性的细胞和合成生物学方面的基本新知识，这将促进建立新的国际联系和网络。这项研究应该会使生物技术部门受益，因为它确定了具有所需生物产出的工程支架的战略，并在大规模细胞生产、免疫治疗、伤口愈合和再生医学等领域得到了应用。

This project aims to determine how cells utilise scaffold-type signalling proteins to orchestrate, over time, diverse cellular responses critical for normal development and physiology. The project expects to generate fundamental new knowledge in cell and synthetic biology with broad relevance that will foster establishment of new international linkages and networks. This research should benefit the biotechnology sector by identifying strategies for engineering scaffolds with desired biological outputs, with applications in areas such as large-scale cell production, immunotherapy, wound healing and regenerative medicine.